TY - JOUR
T1 - Early impairment of long-term depression in the perirhinal cortex of a mouse model of Alzheimer's disease
AU - Tamagnini, Francesco
AU - Burattini, Costanza
AU - Casoli, Tiziana
AU - Balietti, Marta
AU - Fattoretti, Patrizia
AU - Aicardi, Giorgio
PY - 2012/4/1
Y1 - 2012/4/1
N2 - Visual recognition memory is early impaired in Alzheimer's disease. Long-term depression of synaptic transmission in the perirhinal cortex is critically involved in this form of memory. We found that synaptic transmission was impaired in perirhinal cortex slices obtained from 3-month-old Tg2576 mice, and that 3,000 pulses at 5Hz induced long-term depression in perirhinal cortex slices from age-matched control mice, but not in those from Tg2576 mice. To our knowledge, these data provide the first evidence of synaptic transmission and long-term depression impairment in the perirhinal cortex in an animal model of Alzheimer's disease, and the earliest synaptic deficit in Tg2576 mice.
AB - Visual recognition memory is early impaired in Alzheimer's disease. Long-term depression of synaptic transmission in the perirhinal cortex is critically involved in this form of memory. We found that synaptic transmission was impaired in perirhinal cortex slices obtained from 3-month-old Tg2576 mice, and that 3,000 pulses at 5Hz induced long-term depression in perirhinal cortex slices from age-matched control mice, but not in those from Tg2576 mice. To our knowledge, these data provide the first evidence of synaptic transmission and long-term depression impairment in the perirhinal cortex in an animal model of Alzheimer's disease, and the earliest synaptic deficit in Tg2576 mice.
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U2 - 10.1089/rej.2011.1311
DO - 10.1089/rej.2011.1311
M3 - Article
C2 - 22533438
AN - SCOPUS:84860274804
VL - 15
SP - 231
EP - 234
JO - Rejuvenation Research
JF - Rejuvenation Research
SN - 1549-1684
IS - 2
ER -