Early impairment of long-term depression in the perirhinal cortex of a mouse model of Alzheimer's disease

Francesco Tamagnini, Costanza Burattini, Tiziana Casoli, Marta Balietti, Patrizia Fattoretti, Giorgio Aicardi

Research output: Contribution to journalArticle

Abstract

Visual recognition memory is early impaired in Alzheimer's disease. Long-term depression of synaptic transmission in the perirhinal cortex is critically involved in this form of memory. We found that synaptic transmission was impaired in perirhinal cortex slices obtained from 3-month-old Tg2576 mice, and that 3,000 pulses at 5Hz induced long-term depression in perirhinal cortex slices from age-matched control mice, but not in those from Tg2576 mice. To our knowledge, these data provide the first evidence of synaptic transmission and long-term depression impairment in the perirhinal cortex in an animal model of Alzheimer's disease, and the earliest synaptic deficit in Tg2576 mice.

Original languageEnglish
Pages (from-to)231-234
Number of pages4
JournalRejuvenation Research
Volume15
Issue number2
DOIs
Publication statusPublished - Apr 1 2012

ASJC Scopus subject areas

  • Ageing
  • Geriatrics and Gerontology

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