Early increase of a new platelet coagulant activity in rats fed a thrombogenic diet

E. Tremoli, M. Colucci, M. B. Donati, N. Semeraro

Research output: Contribution to journalArticlepeer-review

Abstract

A recently described platelet coagulant activity (factor X activating activity), whose pathophysiological significance is as yet unknown, was studied in rats fed a fat-rich (thrombogenic) diet for 1, 2 and 7 weeks and compared to rats fed normal laboratory chow. Whatever the duration of the special feeding period, a highly significant shortening of the clotting time, used for measuring this activity, was observed. When the platelet coagulant activity of individual "fat-fed" rats was quantitated by reference to that of individual control animals, we found a mean increase of 350% (n = 9) after one week and 267% (n = 3) after two weeks of dietary treatment. Partial thromboplastin time, thrombin time and soluble fibrin monomer complexes did not differ in control and treated animals. It seems that platelet coagulant activity, as measured in our test system, is one of the first laboratory parameters to be modified by fatrich diets. These findings may be relevant to an understanding of the role of platelet coagulant activities other than platelet factor 3 in thrombotic phenomena.

Original languageEnglish
Pages (from-to)239-244
Number of pages6
JournalAtherosclerosis
Volume33
Issue number2
DOIs
Publication statusPublished - 1979

Keywords

  • Dietary fats
  • Platelet coagulant activity
  • Platelets
  • Thrombotic tendency

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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