Early Initiation of Sacubitril/Valsartan in Patients with Chronic Heart Failure After Acute Decompensation: A Case Series Analysis

Domenico Acanfora, Pietro Scicchitano, Chiara Acanfora, Roberto Maestri, Fernando Goglia, Raffaele Antonelli Incalzi, Alessandro Santo Bortone, Marco Matteo Ciccone, Massimo Uguccioni, Gerardo Casucci

Research output: Contribution to journalArticlepeer-review


BACKGROUND AND OBJECTIVE: Sacubitril/valsartan improved the prognosis of patients with heart failure with reduced ejection fraction in the PARADIGM-HF study. Recently, the TRANSITION and PIONEER-HF studies demonstrated the safety and efficacy of sacubitril/valsartan in patients hospitalized for acute decompensated heart failure, with treatment initiated after hemodynamic and clinical stabilization. In this case series study, we assessed the short-term effects of sacubitril/valsartan on exercise capacity, inflammation, and biomarkers in patients with acute decompensated heart failure.

METHODS: Patients admitted for acute decompensated heart failure to the Department of Internal Medicine of Telese Terme Hospital and Cardiovascular Department, University of Bari, from 9 March, 2017 to 9 June, 2018 were enrolled. Following hemodynamic stabilization, patients initiated sacubitril/valsartan 24/26 mg twice a day for 4 weeks, with up-titration to 49/51 mg twice a day based on tolerability after 1 week. Efficacy outcomes included the 6-min walking test, N-terminal pro-B-type natriuretic peptide, high-sensitivity C-reactive protein, and lymphocyte count. Safety outcomes included renal function, hyperkalemia, and symptomatic hypotension.

RESULTS: In total, 40 patients completed the study and 27 (67.5%) patients were up-titrated. Compared with baseline, exercise capacity and relative lymphocyte count increased significantly after 4 weeks of treatment, while N-terminal pro-B-type natriuretic peptide and high-sensitivity C-reactive protein decreased significantly. N-terminal pro-B-type natriuretic peptide and relative lymphocyte count independently predicted the 6-min walking test distance (p = 0.021). No patients experienced any relevant side effects.

CONCLUSIONS: Early initiation of sacubitril/valsartan in patients with heart failure with reduced ejection fraction after acute decompensated heart failure may be safe and effective in terms of functional capacity and biomarkers.

Original languageEnglish
Pages (from-to)493-501
Number of pages9
JournalClinical Drug Investigation
Issue number5
Publication statusPublished - May 2020


  • Aminobutyrates/therapeutic use
  • Angiotensin Receptor Antagonists/therapeutic use
  • Biomarkers/metabolism
  • Drug Combinations
  • Female
  • Heart Failure/drug therapy
  • Hospitalization
  • Humans
  • Male
  • Middle Aged
  • Prognosis
  • Tetrazoles/therapeutic use

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