Early intervention in Crohn's disease: Towards disease modification trials

Silvio Danese, Gionata Fiorino, Laurent Peyrin-Biroulet

Research output: Contribution to journalArticle

Abstract

Crohn's disease (CD) is a chronic progressive destructive inflammatory bowel disease. As in rheumatoid arthritis, there is increasing evidence that early treatment initiation with disease-modifying agents, such as biological drugs, may lead to complete disease control, prevention of disease progression thus protecting against irreversible damage and restoration of normal quality of life. Data from randomised clinical trials with immunosuppressants and biologics suggest that treating patients with a disease duration of <2 years and an absence of complications may significantly reduce the risk for complications and increase time in remission in patients with CD. Moreover, rapid disease control may effectively prevent disease progression and allow dose reduction or even withdrawal of treatment, reducing the risk of long-term adverse events and healthcare costs. However, prospective disease modification trials are needed to confirm these initial results. Here we review the literature regarding early intervention in adult patients with CD and propose criteria for future disease modification trials.

Original languageEnglish
Pages (from-to)2179-2187
Number of pages9
JournalGut
Volume66
Issue number12
DOIs
Publication statusPublished - Dec 1 2017

Keywords

  • Crohn's disease
  • immunoregulation
  • pharmacotherapy

ASJC Scopus subject areas

  • Gastroenterology

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