Early intracranial haemorrhages in acute promyelocytic leukaemia: analysis of neuroradiological and clinico-biological parameters

Carmelo Gurnari, Massimo Breccia, Francesca Di Giuliano, Emilia Scalzulli, Mariadomenica Divona, Alfonso Piciocchi, Laura Cicconi, Eleonora De Bellis, Adriano Venditti, Maria Ilaria Del Principe, William Arcese, Francesco Lo-Coco, Francesco Garaci, Maria Teresa Voso

Research output: Contribution to journalArticlepeer-review

Abstract

Acute promyelocytic leukaemia (APL) represents a modern success of precision medicine. However, fatalities occurring within the first 30 days of induction treatment, in particular intracranial haemorrhage (ICH), remain the main causes of death. We studied the clinico-biological characteristics of 13 patients with APL who experienced ICH. Compared to 85 patients without this complication, patients with ICH were older and more frequently had high-risk APL. Moreover, positivity for the ‘swirl’ sign at neuroradiological imaging and hydrocephalus were predictors of a fatal outcome, together with lower fibrinogen, prolonged international normalized ratio (INR) and higher lactate dehydrogenase levels.

Original languageEnglish
JournalBritish Journal of Haematology
DOIs
Publication statusE-pub ahead of print - Jul 2020

Keywords

  • acute promyelocytic leukaemia
  • early death
  • intracranial haemorrhage

ASJC Scopus subject areas

  • Hematology

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