TY - JOUR
T1 - Early invasive diagnostic techniques in pregnant women who are infected with the HIV
T2 - A multicenter case series
AU - Somigliana, Edgardo
AU - Bucceri, Anna Maria
AU - Tibaldi, Cecilia
AU - Alberico, Salvatore
AU - Ravizza, Marina
AU - Savasi, Valeria
AU - Marini, Silvia
AU - Matrone, Roberta
AU - Pardi, Giorgio
PY - 2005/8
Y1 - 2005/8
N2 - Objective: Studies that mostly were conducted before the widespread use of combination antiretroviral treatments have reported that antenatal invasive procedures markedly increase the risk of human immunodeficiency virus vertical transmission. We aimed to evaluate the vertical transmission rate and other maternal and neonatal complications among women who were infected with human immunodeficiency virus who underwent antenatal invasive procedures during the second trimester of pregnancy and who were delivered after the advent of antiretroviral regimens. Study design: We conducted a multicenter case series of women who were infected with human immunodeficiency virus who underwent amniocentesis or chorionic villus sampling or cordocentesis during the second trimester of pregnancy and who were delivered after January 1, 1997. Results: Sixty-three of 775 recruited women (8.1%) had performed early invasive diagnostic techniques. This rate has improved progressively from 4% in 1997 to 14%. Two of 60 viable infants (3.3%; 95% CI, 0.6%-10.1%) were infected with the human immunodeficiency virus. This rate did not differ significantly from the transmission rate that was observed in women who did not undergo antenatal invasive techniques (1.7%; P = .30). Conclusion: The current risk of human immunodeficiency virus vertical transmission that is associated with early invasive diagnostic techniques is lower than previously reported.
AB - Objective: Studies that mostly were conducted before the widespread use of combination antiretroviral treatments have reported that antenatal invasive procedures markedly increase the risk of human immunodeficiency virus vertical transmission. We aimed to evaluate the vertical transmission rate and other maternal and neonatal complications among women who were infected with human immunodeficiency virus who underwent antenatal invasive procedures during the second trimester of pregnancy and who were delivered after the advent of antiretroviral regimens. Study design: We conducted a multicenter case series of women who were infected with human immunodeficiency virus who underwent amniocentesis or chorionic villus sampling or cordocentesis during the second trimester of pregnancy and who were delivered after January 1, 1997. Results: Sixty-three of 775 recruited women (8.1%) had performed early invasive diagnostic techniques. This rate has improved progressively from 4% in 1997 to 14%. Two of 60 viable infants (3.3%; 95% CI, 0.6%-10.1%) were infected with the human immunodeficiency virus. This rate did not differ significantly from the transmission rate that was observed in women who did not undergo antenatal invasive techniques (1.7%; P = .30). Conclusion: The current risk of human immunodeficiency virus vertical transmission that is associated with early invasive diagnostic techniques is lower than previously reported.
KW - Amniocentesis
KW - Chorionic villus sampling
KW - Cordocentesis
KW - Human immunodeficiency virus
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U2 - 10.1016/j.ajog.2004.12.087
DO - 10.1016/j.ajog.2004.12.087
M3 - Article
C2 - 16098867
AN - SCOPUS:23844545135
VL - 193
SP - 437
EP - 442
JO - American Journal of Obstetrics and Gynecology
JF - American Journal of Obstetrics and Gynecology
SN - 0002-9378
IS - 2
ER -