Abstract
Background and aims: Although it is generally accepted that non alcoholic fatty liver disease (NAFLD) is linked to increased risk of cardiovascular disease, the presence of abnormalities in cardiac function among NAFLD children is limited and controversial. Aim of the study was to detect cardiac abnormalities/dysfunction in a paediatric population of NAFLD. Methods and results: Anthropometric, laboratory, cardiovascular fitness, 24h blood pressure monitoring and Doppler echocardiography parameters were obtained in 50 untreated children (37 males; mean age 12.2+2.5) with biopsy-proven NAFLD.Abnormalities in both cardiac function and geometry could be identified in the whole study population: prevalence of about 35% in left ventricular hypertrophy, 14% of concentric remodelling and 16% of left atrial dilatation. Furthermore children with NAFLD (NAS score 5). After adjusting for age, sex and BMI, a positive correlation was found only between LV mass and NAS score (p
| Original language | English |
|---|---|
| Pages (from-to) | 72-74 |
| Number of pages | 3 |
| Journal | Nutrition, Metabolism and Cardiovascular Diseases |
| Volume | 24 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Cardiovascular alteration
- NAFLD
- Obesity
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
- Endocrinology, Diabetes and Metabolism
- Cardiology and Cardiovascular Medicine
Cite this
Early left ventricular abnormality/dysfunction in obese children affected by NAFLD. / Fintini, D.; Chinali, M.; Cafiero, G.; Esposito, C.; Giordano, U.; Turchetta, A.; Pescosolido, S.; Pongiglione, G.; Nobili, V.
In: Nutrition, Metabolism and Cardiovascular Diseases, Vol. 24, No. 1, 2014, p. 72-74.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early left ventricular abnormality/dysfunction in obese children affected by NAFLD
AU - Fintini, D.
AU - Chinali, M.
AU - Cafiero, G.
AU - Esposito, C.
AU - Giordano, U.
AU - Turchetta, A.
AU - Pescosolido, S.
AU - Pongiglione, G.
AU - Nobili, V.
PY - 2014
Y1 - 2014
N2 - Background and aims: Although it is generally accepted that non alcoholic fatty liver disease (NAFLD) is linked to increased risk of cardiovascular disease, the presence of abnormalities in cardiac function among NAFLD children is limited and controversial. Aim of the study was to detect cardiac abnormalities/dysfunction in a paediatric population of NAFLD. Methods and results: Anthropometric, laboratory, cardiovascular fitness, 24h blood pressure monitoring and Doppler echocardiography parameters were obtained in 50 untreated children (37 males; mean age 12.2+2.5) with biopsy-proven NAFLD.Abnormalities in both cardiac function and geometry could be identified in the whole study population: prevalence of about 35% in left ventricular hypertrophy, 14% of concentric remodelling and 16% of left atrial dilatation. Furthermore children with NAFLD (NAS score 5). After adjusting for age, sex and BMI, a positive correlation was found only between LV mass and NAS score (p
AB - Background and aims: Although it is generally accepted that non alcoholic fatty liver disease (NAFLD) is linked to increased risk of cardiovascular disease, the presence of abnormalities in cardiac function among NAFLD children is limited and controversial. Aim of the study was to detect cardiac abnormalities/dysfunction in a paediatric population of NAFLD. Methods and results: Anthropometric, laboratory, cardiovascular fitness, 24h blood pressure monitoring and Doppler echocardiography parameters were obtained in 50 untreated children (37 males; mean age 12.2+2.5) with biopsy-proven NAFLD.Abnormalities in both cardiac function and geometry could be identified in the whole study population: prevalence of about 35% in left ventricular hypertrophy, 14% of concentric remodelling and 16% of left atrial dilatation. Furthermore children with NAFLD (NAS score 5). After adjusting for age, sex and BMI, a positive correlation was found only between LV mass and NAS score (p
KW - Cardiovascular alteration
KW - NAFLD
KW - Obesity
UR - http://www.scopus.com/inward/record.url?scp=84894254732&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84894254732&partnerID=8YFLogxK
U2 - 10.1016/j.numecd.2013.06.005
DO - 10.1016/j.numecd.2013.06.005
M3 - Article
VL - 24
SP - 72
EP - 74
JO - Nutrition, Metabolism and Cardiovascular Diseases
JF - Nutrition, Metabolism and Cardiovascular Diseases
SN - 0939-4753
IS - 1
ER -