Early liaisons between cells of the innate immune system in inflamed peripheral tissues

Alessandro Moretta, Emanuela Marcenaro, Simona Sivori, Mariella Della Chiesa, Massimo Vitale, Lorenzo Moretta

Research output: Contribution to journalArticlepeer-review

Abstract

The crosstalk between natural killer (NK) cells and myeloid dendritic cells (DCs) results in NK-cell activation and DC maturation. Activated NK cells acquire the ability to kill DCs that have failed to undergo complete maturation ('DC editing'). Recent studies have revealed that this crosstalk can be promoted by pathogen-derived products that activate different innate immune cell types directly and simultaneously through their Toll-like receptors (TLRs). These cells include NK cells and DCs, as well as plasmacytoid DCs (PDCs) and mast cells. This crosstalk can have a great impact on the quality and strength of the subsequent adaptive immune response. Thus, NK cells have an important role in the defense against pathogens, acting as regulatory cells as well as effector cells.

Original languageEnglish
Pages (from-to)668-675
Number of pages8
JournalTrends in Immunology
Volume26
Issue number12
DOIs
Publication statusPublished - Dec 2005

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

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