TY - JOUR
T1 - Early liaisons between cells of the innate immune system in inflamed peripheral tissues
AU - Moretta, Alessandro
AU - Marcenaro, Emanuela
AU - Sivori, Simona
AU - Chiesa, Mariella Della
AU - Vitale, Massimo
AU - Moretta, Lorenzo
PY - 2005/12
Y1 - 2005/12
N2 - The crosstalk between natural killer (NK) cells and myeloid dendritic cells (DCs) results in NK-cell activation and DC maturation. Activated NK cells acquire the ability to kill DCs that have failed to undergo complete maturation ('DC editing'). Recent studies have revealed that this crosstalk can be promoted by pathogen-derived products that activate different innate immune cell types directly and simultaneously through their Toll-like receptors (TLRs). These cells include NK cells and DCs, as well as plasmacytoid DCs (PDCs) and mast cells. This crosstalk can have a great impact on the quality and strength of the subsequent adaptive immune response. Thus, NK cells have an important role in the defense against pathogens, acting as regulatory cells as well as effector cells.
AB - The crosstalk between natural killer (NK) cells and myeloid dendritic cells (DCs) results in NK-cell activation and DC maturation. Activated NK cells acquire the ability to kill DCs that have failed to undergo complete maturation ('DC editing'). Recent studies have revealed that this crosstalk can be promoted by pathogen-derived products that activate different innate immune cell types directly and simultaneously through their Toll-like receptors (TLRs). These cells include NK cells and DCs, as well as plasmacytoid DCs (PDCs) and mast cells. This crosstalk can have a great impact on the quality and strength of the subsequent adaptive immune response. Thus, NK cells have an important role in the defense against pathogens, acting as regulatory cells as well as effector cells.
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U2 - 10.1016/j.it.2005.09.008
DO - 10.1016/j.it.2005.09.008
M3 - Article
C2 - 16198147
VL - 26
SP - 668
EP - 675
JO - Trends in Immunology
JF - Trends in Immunology
SN - 1471-4906
IS - 12
ER -