Early life factors related to clinical manifestations of atopic disease but not to skin-prick test positivity in young children

Maria Antonietta Stazi, Francesca Sampogna, Giuseppe Montagano, Michele E. Grandolfo, Marie France Couilliot, Isabella Annesi-Maesano

Research output: Contribution to journalArticlepeer-review

Abstract

The relative influence of early life events in the development of IgE-mediated allergy is still undetermined. We investigated early life factors in relation to skin-prick test (SPT) positivity and clinical manifestations of atopic disease in a population-based sample of 201 Italian children (3 months-5 years), after considering their interactions with known determinants of allergy. Among them, 143 children had SPT performed to common allergens. Threatened abortions, general anesthesia at delivery, prematurity, birthweight <2500 g, maternal smoking, dampness and gas heating exposure were all significantly related to an increased risk of frequent rhinitis in the absence of cold (18%). In utero smoking, threatened abortions, fetal health complications, infantile colic, maternal smoking in childhood (satisfactorily correlated with maternal expired CO during the survey) and respiratory infections were all independent determinants of frequent wheezing (23%). Doctor's diagnosis of asthma (3%) was related to in utero smoking, being born in spring, infantile colic and respiratory infections. A simultaneous exposure to in utero smoking and infantile colic put the infants to a fourfold higher risk of frequent wheezing and to a ninefold risk of asthma, respectively. Having a pet and washing blankets at

Original languageEnglish
Pages (from-to)105-112
Number of pages8
JournalPediatric Allergy and Immunology
Volume13
Issue number2
DOIs
Publication statusPublished - 2002

Keywords

  • Abortion
  • Allergic sensitization
  • Atopic disease
  • Carbon monoxide
  • Early life
  • Infantile colic
  • Passive smoking
  • Wheezing

ASJC Scopus subject areas

  • Immunology and Allergy
  • Pediatrics, Perinatology, and Child Health
  • Immunology

Fingerprint

Dive into the research topics of 'Early life factors related to clinical manifestations of atopic disease but not to skin-prick test positivity in young children'. Together they form a unique fingerprint.

Cite this