Early-life gut microbiota under physiological and pathological conditions: The central role of combined meta-omics-based approaches

Federica Del Chierico, Pamela Vernocchi, Luigi Bonizzi, Rita Carsetti, Anna Maria Castellazzi, Bruno Dallapiccola, Willem de Vos, Maria Elisabetta Guerzoni, Melania Manco, Gian Luigi Marseglia, Maurizio Muraca, Paola Roncada, Guglielmo Salvatori, Fabrizio Signore, Andrea Urbani, Lorenza Putignani

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

The establishment of gut microbiota immediately after birth is modulated by different mechanisms that can be considered specific determinants of temporal and spatial variability. Over the last few years, molecular methods have been offering a complementary support to the classical microbiology, often underpowered by its inability to provide unbiased representation of gut microbiota. The advent of high-throughput-omics-based methods has opened new avenues in the knowledge of the gut ecosystem by shedding light on its shape and modulation. Such methods may unveil taxa distribution, role and density of microbial habitants, hence highlighting individual phenotyping (physiological traits) and their relationship with gut dysbiosis, inflammation processes, metabolic disorders (pathological conditions). Synergic meta-omics or "systems biology"-based approaches may concur in providing advanced information on microbiota establishment and pathogen control. During early-life stages this massive amount of data may provide gut microbiota descriptive and functional charts which can be exploited to perform a good practice in childcare and pediatrics, thus providing nutraceutical benefits and endorsing healthy development and aging. This article is part of a Special Issue entitled: Translational Proteomics.

Original languageEnglish
Pages (from-to)4580-4587
Number of pages8
JournalJournal of Proteomics
Volume75
Issue number15
DOIs
Publication statusPublished - Aug 3 2012

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Microbiology
Pediatrics
Pathogens
Ecosystems
Aging of materials
Throughput
Modulation
Dysbiosis
Systems Biology
Microbiota
Dietary Supplements
Proteomics
Ecosystem
Parturition
Inflammation
Gastrointestinal Microbiome

Keywords

  • Early-life gut onset and development
  • Gut microbiota
  • Meta-omics gut charts
  • Personalized medicine

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics

Cite this

Early-life gut microbiota under physiological and pathological conditions : The central role of combined meta-omics-based approaches. / Del Chierico, Federica; Vernocchi, Pamela; Bonizzi, Luigi; Carsetti, Rita; Castellazzi, Anna Maria; Dallapiccola, Bruno; de Vos, Willem; Guerzoni, Maria Elisabetta; Manco, Melania; Marseglia, Gian Luigi; Muraca, Maurizio; Roncada, Paola; Salvatori, Guglielmo; Signore, Fabrizio; Urbani, Andrea; Putignani, Lorenza.

In: Journal of Proteomics, Vol. 75, No. 15, 03.08.2012, p. 4580-4587.

Research output: Contribution to journalArticle

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