Early manifestations of dementing illness: Treatment with glycosaminoglycan polysulfate

Thomas A. Ban; Leslie C. Morey; Olaf K. Fjetland; Franco Rengo; Nicola Ferrara; Virgilio Agnetti; Marina D'onofrio; Giulio Facchini; Fernando Anzivino; Maria Alessandra Perego; Chiara Danese; Antonio Capurso; Antonio Tommasi; Gualtiero Scardigli; Giovanni Jans; Lucilla Parnetti; Umberto Senin; Bruno Bergamasco

doi:10.1016/0278-5846(92)90023-8

Early manifestations of dementing illness: Treatment with glycosaminoglycan polysulfate

Thomas A. Ban, Leslie C. Morey, Olaf K. Fjetland, Franco Rengo, Nicola Ferrara, Virgilio Agnetti, Marina D'onofrio, Giulio Facchini, Fernando Anzivino, Maria Alessandra Perego, Chiara Danese, Antonio Capurso, Antonio Tommasi, Gualtiero Scardigli, Giovanni Jans, Lucilla Parnetti, Umberto Senin, Bruno Bergamasco

Istituti Clinici Scientifici Maugeri Spa – Società Benefit

Research output: Contribution to journal › Article › peer-review

Abstract

1. In a multicenter, placebo-controlled, double-blind clinical trial in 156 elderly patients with psychopathologic symptoms, glycosaminoglycan polysulfate was found to be a therapeutlcally effective agent in the treatment of the earliest manifestations of a dementing process. 2. Treatment with glycosaminoglycan polysulfate in the daily dosage of 600 LRU, administered on the basis of a divided dosage schedule for 24 weeks, was significantly superior to an inactive placebo on several several outcome measures including the SCAG Total and factor scores (i.e., Cognitive Dysfunction, Withdrawal, Agitation/Irritability and Depression), the NOHLIS Total and Fatiguability factor scores, the MMSE, the HAM-D Total and Vegetative Symptoms factor score and the CGI Severity of Illness and Global Improvement. 3. The drug was well tolerated; vital signs and laboratory measures did not show clinically significant changes within the experimental period.

Original language	English
Pages (from-to)	661-676
Number of pages	16
Journal	Progress in Neuro-Psychopharmacology and Biological Psychiatry
Volume	16
Issue number	5
DOIs	https://doi.org/10.1016/0278-5846(92)90023-8
Publication status	Published - 1992

Keywords

dementia
elderly
glycosaminoglycan polysulfate
psychopathologic symptoms
treatment

ASJC Scopus subject areas

Biological Psychiatry
Pharmacology

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Ban, T. A., Morey, L. C., Fjetland, O. K., Rengo, F., Ferrara, N., Agnetti, V., D'onofrio, M., Facchini, G., Anzivino, F., Perego, M. A., Danese, C., Capurso, A., Tommasi, A., Scardigli, G., Jans, G., Parnetti, L., Senin, U., & Bergamasco, B. (1992). Early manifestations of dementing illness: Treatment with glycosaminoglycan polysulfate. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 16(5), 661-676. https://doi.org/10.1016/0278-5846(92)90023-8

Early manifestations of dementing illness : Treatment with glycosaminoglycan polysulfate. / Ban, Thomas A.; Morey, Leslie C.; Fjetland, Olaf K.; Rengo, Franco; Ferrara, Nicola; Agnetti, Virgilio; D'onofrio, Marina; Facchini, Giulio; Anzivino, Fernando; Perego, Maria Alessandra; Danese, Chiara; Capurso, Antonio; Tommasi, Antonio; Scardigli, Gualtiero; Jans, Giovanni; Parnetti, Lucilla; Senin, Umberto; Bergamasco, Bruno.

In: Progress in Neuro-Psychopharmacology and Biological Psychiatry, Vol. 16, No. 5, 1992, p. 661-676.

Research output: Contribution to journal › Article › peer-review

Ban, TA, Morey, LC, Fjetland, OK, Rengo, F, Ferrara, N, Agnetti, V, D'onofrio, M, Facchini, G, Anzivino, F, Perego, MA, Danese, C, Capurso, A, Tommasi, A, Scardigli, G, Jans, G, Parnetti, L, Senin, U & Bergamasco, B 1992, 'Early manifestations of dementing illness: Treatment with glycosaminoglycan polysulfate', Progress in Neuro-Psychopharmacology and Biological Psychiatry, vol. 16, no. 5, pp. 661-676. https://doi.org/10.1016/0278-5846(92)90023-8

Ban, Thomas A. ; Morey, Leslie C. ; Fjetland, Olaf K. ; Rengo, Franco ; Ferrara, Nicola ; Agnetti, Virgilio ; D'onofrio, Marina ; Facchini, Giulio ; Anzivino, Fernando ; Perego, Maria Alessandra ; Danese, Chiara ; Capurso, Antonio ; Tommasi, Antonio ; Scardigli, Gualtiero ; Jans, Giovanni ; Parnetti, Lucilla ; Senin, Umberto ; Bergamasco, Bruno. / Early manifestations of dementing illness : Treatment with glycosaminoglycan polysulfate. In: Progress in Neuro-Psychopharmacology and Biological Psychiatry. 1992 ; Vol. 16, No. 5. pp. 661-676.

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