Early manifestations of dementing illness: Treatment with glycosaminoglycan polysulfate

Thomas A. Ban, Leslie C. Morey, Olaf K. Fjetland, Franco Rengo, Nicola Ferrara, Virgilio Agnetti, Marina D'onofrio, Giulio Facchini, Fernando Anzivino, Maria Alessandra Perego, Chiara Danese, Antonio Capurso, Antonio Tommasi, Gualtiero Scardigli, Giovanni Jans, Lucilla Parnetti, Umberto Senin, Bruno Bergamasco

Research output: Contribution to journalArticlepeer-review


1. In a multicenter, placebo-controlled, double-blind clinical trial in 156 elderly patients with psychopathologic symptoms, glycosaminoglycan polysulfate was found to be a therapeutlcally effective agent in the treatment of the earliest manifestations of a dementing process. 2. Treatment with glycosaminoglycan polysulfate in the daily dosage of 600 LRU, administered on the basis of a divided dosage schedule for 24 weeks, was significantly superior to an inactive placebo on several several outcome measures including the SCAG Total and factor scores (i.e., Cognitive Dysfunction, Withdrawal, Agitation/Irritability and Depression), the NOHLIS Total and Fatiguability factor scores, the MMSE, the HAM-D Total and Vegetative Symptoms factor score and the CGI Severity of Illness and Global Improvement. 3. The drug was well tolerated; vital signs and laboratory measures did not show clinically significant changes within the experimental period.

Original languageEnglish
Pages (from-to)661-676
Number of pages16
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Issue number5
Publication statusPublished - 1992


  • dementia
  • elderly
  • glycosaminoglycan polysulfate
  • psychopathologic symptoms
  • treatment

ASJC Scopus subject areas

  • Biological Psychiatry
  • Pharmacology


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