Early markers of inflammation in a high angiotensin II state - Results of studies in Bartter's/Gitelman's syndromes

Paul A. Davis, Michele Mussap, Elisa Pagnin, Lara Bertipaglia, Vincenzo Savica, Andrea Semplicini, Lorenzo A. Calò

Research output: Contribution to journalArticlepeer-review

Abstract

Background. Inflammation has been increasingly recognized as playing a critical role in hypertension and atherosclerosis as reflected by overexpression and increased production of a variety of pro-inflammatory mediators. As angiotensin II (Ang II) also plays a major role in these diseases, the relationship between inflammation and Ang II has drawn increasing scrutiny. This study explores Ang II effects in Bartter's and Gitelman's syndromes (BS/GS) which do not develop hypertension and related cardiovascular remodelling and atherosclerosis, in spite of high Ang II levels and activation of the renin-angiotensin-aldosterone system while the NO system is up-regulated. Methods. We evaluated the plasma levels of inflammation-associated markers, C-reactive protein (CRP), serum amyloid A (SAA), vascular cell adhesion molecules (VCAM) and intercellular adhesion molecules (ICAM), and the inflammation-related cytokines interleukin-6 (IL-6) and tumour necrosis factor-α (TNF-α) using immunonephelometric and ELISA-based assays. Results. The study demonstrated that all markers of inflammation except TNF-α, were unchanged in BS/GS (2.51±0.62mg/l in BS/GS vs 1.7±0.6in controls for CRP; 4.56±1.09mg/l in BS/GS vs 4.51±1.0 for SAA; 1.84±0.27ng/l in BS/GS vs 2.1±0.3 for IL-6; 449±83 ng/ml in BS/GS vs 410±92 for VCAM and 234±26 ng/ml in BS/GS vs 185±22 for ICAM), while TNF-α was increased (10.5±2.03 vs 3.68±0.2, P=0.0001). Conclusions. The results of this study stress the critical role played by Ang II in controlling vascular biology including inflammation-related processes as well as highlighting the utility of BS/GS in investigating these pathways.

Original languageEnglish
Pages (from-to)1697-1701
Number of pages5
JournalNephrology Dialysis Transplantation
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2006

Keywords

  • Angiotensin II
  • Atherosclerosis
  • Bartter's
  • Gitelman's syndrome
  • Hypertension
  • inflammation
  • Syndrome

ASJC Scopus subject areas

  • Nephrology
  • Transplantation

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