Early microscopic evidence for endothelial damage in arterial microanastomoses

M. Benazzo, M. Casasco, G. Bertino, A. Occhini, A. Casasco

Research output: Contribution to journalArticle

Abstract

Thrombosis of the arterial microanastomosis is the major reason for flap complications. Thrombus formation can occur rapidly at the site of anastomosis, or it may be delayed in developing, inducing secondary ischemia. The damaged endothelial cells and the exposed connective tissue play an important role in the molecular and cell mechanisms of coagulation and thrombosis. For this reason the early morphological changes in the endothelial cell layer after arterial microanastomoses in the rat were investigated. The results showed that the anastomotic site appeared completely sealed, with cut ends protruding into the vessel lumen. Extensive deendothelialized areas with fibrin deposition were visible between surgical microclamps on the inner surface of the artery. For this reason we believe that the damaged endothelium and exposed connective tissue elements are the primary cause of thrombin formation, platelet accumulation, and thrombosis at the anastomotic site. The reconstructive surgeon must employ a very meticulous microvascular technique to minimize damage to the vascular endothelium.

Original languageEnglish
Pages (from-to)26-28
Number of pages3
JournalEuropean Journal of Plastic Surgery
Volume26
Issue number1
Publication statusPublished - Apr 2003

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Thrombosis
Connective Tissue
Endothelial Cells
Vascular Endothelium
Fibrin
Thrombin
Endothelium
Blood Platelets
Ischemia
Arteries

Keywords

  • Endothelium
  • Flaps
  • Microanastomoses
  • Thrombus

ASJC Scopus subject areas

  • Surgery

Cite this

Early microscopic evidence for endothelial damage in arterial microanastomoses. / Benazzo, M.; Casasco, M.; Bertino, G.; Occhini, A.; Casasco, A.

In: European Journal of Plastic Surgery, Vol. 26, No. 1, 04.2003, p. 26-28.

Research output: Contribution to journalArticle

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