TY - JOUR
T1 - Early mortality from malignant mesothelioma in Italy as a proxy of environmental exposure to asbestos in children
AU - Fazzo, Lucia
AU - Minelli, Giada
AU - Bruno, Caterina
AU - Comba, Pietro
AU - Conti, Susanna
AU - De Santis, Marco
AU - Zona, Amerigo
AU - Binazzi, Alessandra
AU - Magnani, Corrado
AU - Marinaccio, Alessandro
AU - Iavarone, Ivano
N1 - Publisher Copyright:
© 2020 Istituto Superiore di Sanita. All rights reserved.
PY - 2020
Y1 - 2020
N2 - Malignant mesothelioma (MM) is a rare neoplasm caused by asbestos. Mortality from MM in ≤50 years old people, considering the long latency, is likely related to asbestos exposure in childhood. Mortality from MM (C45, ICD10 code) is described among ≤50 years (ys) old people in Italy, in 2003-2016. National and regional Standardized Rates (SRs) were computed by age-class. The North-South trend of regional SRs, increasing in >50ys age-class, showed a flat cline in ≤50ys old people. Municipal Standardized Mortality Ratios (SMRs) were computed, with respect to regional figures, for ≤50 ys old population. In Italy, 487 people ≤50 ys old died from MM, in 2003-2016 (2.5% of all MM deaths), corresponding to 35/year. The highest SMRs were observed in Northern Regions, the most industrialized areas. Exceeding SMRs were found in 10 municipalities where former asbestos-cement plants, shipyards, and a quarry contaminated by fluoroedenite fibres were present. Early mortality from MM, proxy of childhood environmental asbestos exposure, deserves particular concern.
AB - Malignant mesothelioma (MM) is a rare neoplasm caused by asbestos. Mortality from MM in ≤50 years old people, considering the long latency, is likely related to asbestos exposure in childhood. Mortality from MM (C45, ICD10 code) is described among ≤50 years (ys) old people in Italy, in 2003-2016. National and regional Standardized Rates (SRs) were computed by age-class. The North-South trend of regional SRs, increasing in >50ys age-class, showed a flat cline in ≤50ys old people. Municipal Standardized Mortality Ratios (SMRs) were computed, with respect to regional figures, for ≤50 ys old population. In Italy, 487 people ≤50 ys old died from MM, in 2003-2016 (2.5% of all MM deaths), corresponding to 35/year. The highest SMRs were observed in Northern Regions, the most industrialized areas. Exceeding SMRs were found in 10 municipalities where former asbestos-cement plants, shipyards, and a quarry contaminated by fluoroedenite fibres were present. Early mortality from MM, proxy of childhood environmental asbestos exposure, deserves particular concern.
KW - Asbestos
KW - Epidemiology
KW - Mesothelioma
KW - Mortality
KW - Young adults
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U2 - 10.4415/ANN_20_04_10
DO - 10.4415/ANN_20_04_10
M3 - Review article
C2 - 33346174
AN - SCOPUS:85098744726
VL - 56
SP - 478
EP - 486
JO - Annali dell'Istituto Superiore di Sanita
JF - Annali dell'Istituto Superiore di Sanita
SN - 0021-2571
IS - 4
ER -