Early mortality from malignant mesothelioma in Italy as a proxy of environmental exposure to asbestos in children

Lucia Fazzo, Giada Minelli, Caterina Bruno, Pietro Comba, Susanna Conti, Marco De Santis, Amerigo Zona, Alessandra Binazzi, Corrado Magnani, Alessandro Marinaccio, Ivano Iavarone

Research output: Contribution to journalReview articlepeer-review

Abstract

Malignant mesothelioma (MM) is a rare neoplasm caused by asbestos. Mortality from MM in ≤50 years old people, considering the long latency, is likely related to asbestos exposure in childhood. Mortality from MM (C45, ICD10 code) is described among ≤50 years (ys) old people in Italy, in 2003-2016. National and regional Standardized Rates (SRs) were computed by age-class. The North-South trend of regional SRs, increasing in >50ys age-class, showed a flat cline in ≤50ys old people. Municipal Standardized Mortality Ratios (SMRs) were computed, with respect to regional figures, for ≤50 ys old population. In Italy, 487 people ≤50 ys old died from MM, in 2003-2016 (2.5% of all MM deaths), corresponding to 35/year. The highest SMRs were observed in Northern Regions, the most industrialized areas. Exceeding SMRs were found in 10 municipalities where former asbestos-cement plants, shipyards, and a quarry contaminated by fluoroedenite fibres were present. Early mortality from MM, proxy of childhood environmental asbestos exposure, deserves particular concern.

Original languageEnglish
Pages (from-to)478-486
Number of pages9
JournalAnnali dell'Istituto Superiore di Sanita
Volume56
Issue number4
DOIs
Publication statusPublished - 2020

Keywords

  • Asbestos
  • Epidemiology
  • Mesothelioma
  • Mortality
  • Young adults

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health

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