Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease

Antonio Luiz Pinho Ribeiro, Luis Eduardo Díaz Giménez, Ciria Carolina Quintero Hernández, Antonio Carlos Campos de Carvalho, Mauro Martins Teixeira, Valesca Costa Guedes, Márcio Vinícius Lins Barros, Federico Lombardi, Manoel Otávio da Costa Rocha

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Background: Autoimmunity and dysautonomia are established features of Chagas disease (ChD) that could be related to its pathogenesis. Our objective was to assess heart rate variability (HRV) and levels of anti-M2 receptors autoantibodies in ChD patients with and without left ventricular (LV) dysfunction, in order to establish if these abnormalities occur early and concomitantly in the course of the illness. Methods: ChD patients (n = 75) and healthy controls (n = 14) underwent a standardized protocol including Doppler echocardiogram, Holter monitoring, HRV analysis, and measurement of anti-M2 receptors autoantibodies (ELISA). ChD patients were divided accordingly by the absence (group 1, n = 45) or presence (group 2, n = 30) of LV dysfunction, defined as reduced LV ejection fraction (<55%) or regional wall motion abnormalities (including ventricular aneurysm). Results: Both ChD groups displayed increased optical density values of anti-M2 cholinergic autoantibodies (Median (IQR): control = 1.98(0.51); ChD 1 = 2.76(0.97); ChD 2 = 2.72(1.34), p <.001) and reduced HF power of spectral analysis of HRV when compared to controls (Median (IQR) in ms2: control = 1087(2284); ChD 1 = 286(763); ChD 2 = 285(763), p <.001). M2 levels were significantly correlated with HF power values (r = - 0.32, p = 0.023), but not with LV ejection fraction. Conclusions: Anti-muscarinic autoantibodies and abnormal vagal modulation occur early in ChD patients, independently of the presence of LV dysfunction. Levels of antibodies against M2 muscarinic receptors were significantly and negatively correlated with HRV index HF power, suggesting an inhibitory effect of autoantibodies in vagal function.

Original languageEnglish
Pages (from-to)59-63
Number of pages5
JournalInternational Journal of Cardiology
Volume117
Issue number1
DOIs
Publication statusPublished - Apr 12 2007

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Chagas Disease
Autoantibodies
Cholinergic Agents
Left Ventricular Dysfunction
Heart Rate
Stroke Volume
Primary Dysautonomias
Muscarinic M2 Receptors
Ambulatory Electrocardiography
Cholinergic Antagonists
Autoimmunity
Aneurysm
Enzyme-Linked Immunosorbent Assay

Keywords

  • Autonomic nervous system
  • Chagas disease
  • Heart rate variability
  • Neurotransmitter receptor autoantibodies

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Ribeiro, A. L. P., Giménez, L. E. D., Hernández, C. C. Q., de Carvalho, A. C. C., Teixeira, M. M., Guedes, V. C., ... da Costa Rocha, M. O. (2007). Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease. International Journal of Cardiology, 117(1), 59-63. https://doi.org/10.1016/j.ijcard.2006.04.053

Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease. / Ribeiro, Antonio Luiz Pinho; Giménez, Luis Eduardo Díaz; Hernández, Ciria Carolina Quintero; de Carvalho, Antonio Carlos Campos; Teixeira, Mauro Martins; Guedes, Valesca Costa; Barros, Márcio Vinícius Lins; Lombardi, Federico; da Costa Rocha, Manoel Otávio.

In: International Journal of Cardiology, Vol. 117, No. 1, 12.04.2007, p. 59-63.

Research output: Contribution to journalArticle

Ribeiro, ALP, Giménez, LED, Hernández, CCQ, de Carvalho, ACC, Teixeira, MM, Guedes, VC, Barros, MVL, Lombardi, F & da Costa Rocha, MO 2007, 'Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease', International Journal of Cardiology, vol. 117, no. 1, pp. 59-63. https://doi.org/10.1016/j.ijcard.2006.04.053
Ribeiro ALP, Giménez LED, Hernández CCQ, de Carvalho ACC, Teixeira MM, Guedes VC et al. Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease. International Journal of Cardiology. 2007 Apr 12;117(1):59-63. https://doi.org/10.1016/j.ijcard.2006.04.053
Ribeiro, Antonio Luiz Pinho ; Giménez, Luis Eduardo Díaz ; Hernández, Ciria Carolina Quintero ; de Carvalho, Antonio Carlos Campos ; Teixeira, Mauro Martins ; Guedes, Valesca Costa ; Barros, Márcio Vinícius Lins ; Lombardi, Federico ; da Costa Rocha, Manoel Otávio. / Early occurrence of anti-muscarinic autoantibodies and abnormal vagal modulation in Chagas disease. In: International Journal of Cardiology. 2007 ; Vol. 117, No. 1. pp. 59-63.
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AU - de Carvalho, Antonio Carlos Campos

AU - Teixeira, Mauro Martins

AU - Guedes, Valesca Costa

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