Early-onset absence epilepsy aggravated by valproic acid: A video-EEG report

Vincenzo Belcastro, Roberto Horacio Caraballo, Antonino Romeo, Pasquale Striano

Research output: Contribution to journalArticlepeer-review


Early-onset absence epilepsy refers to patients with absence seizures beginning before age 4 and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a boy with absence seizures with onset at age 11 months, whose seizures increased in frequency after the introduction of valproic acid (VPA) treatment and substantially improved upon cessation of treatment. The mechanism of seizure worsening did not involve VPA toxicity, encephalopathy, Glut-1 deficiency or overdosage, and the reason for absence seizure aggravation remained unclear. The patient showed complete control of absence seizures with levetiracetam treatment and the course was benign, both in terms of seizure control and neuropsychological aspects. The similar overall electroclinical picture and outcome between children with early-onset absences and those with CAE support the view that these conditions are a continuum within the wide spectrum of IGE.

Original languageEnglish
Pages (from-to)440-443
Number of pages4
JournalEpileptic Disorders
Issue number4
Publication statusPublished - Dec 2013


  • Early-onset absence epilepsy
  • GLUT-1 deficiency
  • Myoclonic epilepsy of infancy
  • Seizure worsening

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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