Abstract
Early-onset absence epilepsy refers to patients with absence seizures beginning before age 4 and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a boy with absence seizures with onset at age 11 months, whose seizures increased in frequency after the introduction of valproic acid (VPA) treatment and substantially improved upon cessation of treatment. The mechanism of seizure worsening did not involve VPA toxicity, encephalopathy, Glut-1 deficiency or overdosage, and the reason for absence seizure aggravation remained unclear. The patient showed complete control of absence seizures with levetiracetam treatment and the course was benign, both in terms of seizure control and neuropsychological aspects. The similar overall electroclinical picture and outcome between children with early-onset absences and those with CAE support the view that these conditions are a continuum within the wide spectrum of IGE.
| Original language | English |
|---|---|
| Pages (from-to) | 440-443 |
| Number of pages | 4 |
| Journal | Epileptic Disorders |
| Volume | 15 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Dec 2013 |
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Keywords
- Early-onset absence epilepsy
- GLUT-1 deficiency
- Myoclonic epilepsy of infancy
- Seizure worsening
ASJC Scopus subject areas
- Clinical Neurology
- Neurology
Cite this
Early-onset absence epilepsy aggravated by valproic acid : A video-EEG report. / Belcastro, Vincenzo; Caraballo, Roberto Horacio; Romeo, Antonino; Striano, Pasquale.
In: Epileptic Disorders, Vol. 15, No. 4, 12.2013, p. 440-443.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early-onset absence epilepsy aggravated by valproic acid
T2 - A video-EEG report
AU - Belcastro, Vincenzo
AU - Caraballo, Roberto Horacio
AU - Romeo, Antonino
AU - Striano, Pasquale
PY - 2013/12
Y1 - 2013/12
N2 - Early-onset absence epilepsy refers to patients with absence seizures beginning before age 4 and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a boy with absence seizures with onset at age 11 months, whose seizures increased in frequency after the introduction of valproic acid (VPA) treatment and substantially improved upon cessation of treatment. The mechanism of seizure worsening did not involve VPA toxicity, encephalopathy, Glut-1 deficiency or overdosage, and the reason for absence seizure aggravation remained unclear. The patient showed complete control of absence seizures with levetiracetam treatment and the course was benign, both in terms of seizure control and neuropsychological aspects. The similar overall electroclinical picture and outcome between children with early-onset absences and those with CAE support the view that these conditions are a continuum within the wide spectrum of IGE.
AB - Early-onset absence epilepsy refers to patients with absence seizures beginning before age 4 and comprises a heterogeneous group of epilepsies. Onset of absence seizures in the first year of life is very rare. We report a boy with absence seizures with onset at age 11 months, whose seizures increased in frequency after the introduction of valproic acid (VPA) treatment and substantially improved upon cessation of treatment. The mechanism of seizure worsening did not involve VPA toxicity, encephalopathy, Glut-1 deficiency or overdosage, and the reason for absence seizure aggravation remained unclear. The patient showed complete control of absence seizures with levetiracetam treatment and the course was benign, both in terms of seizure control and neuropsychological aspects. The similar overall electroclinical picture and outcome between children with early-onset absences and those with CAE support the view that these conditions are a continuum within the wide spectrum of IGE.
KW - Early-onset absence epilepsy
KW - GLUT-1 deficiency
KW - Myoclonic epilepsy of infancy
KW - Seizure worsening
UR - http://www.scopus.com/inward/record.url?scp=84890868439&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84890868439&partnerID=8YFLogxK
U2 - 10.1684/epd.2013.0616
DO - 10.1684/epd.2013.0616
M3 - Article
C2 - 24169439
AN - SCOPUS:84890868439
VL - 15
SP - 440
EP - 443
JO - Epileptic Disorders
JF - Epileptic Disorders
SN - 1294-9361
IS - 4
ER -