TY - JOUR
T1 - Early onset epilepsy caused by low-grade epilepsy-associated tumors and focal meningeal involvement
AU - De Palma, Luca
AU - Pepi, Chiara
AU - De Benedictis, Alessandro
AU - Pietrafusa, Nicola
AU - Mastronuzzi, Angela
AU - Cacchione, Antonella
AU - Carfì-Pavia, Giusy
AU - Rossi-Espagnet, Camilla
AU - Diomedi-Camassei, Francesca
AU - Rossi, Sabrina
AU - Napolitano, Antonio
AU - Carai, Andrea
AU - Colafati, Giovanna Stefania
AU - Longo, Daniela
AU - Curatolo, Paolo
AU - Vigevano, Federico
AU - Marras, Carlo Efisio
AU - Specchio, Nicola
N1 - Publisher Copyright:
© 2020 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2020/10
Y1 - 2020/10
N2 - Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug-and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs.
AB - Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug-and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs.
KW - Drug resistant epilepsy
KW - Epilepsy
KW - Meningeal neoplasms
KW - Neuroepithelial tumors
KW - Pediatrics
KW - Surgery
KW - Temporal lobe
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U2 - 10.3390/brainsci10100752
DO - 10.3390/brainsci10100752
M3 - Article
AN - SCOPUS:85092695312
VL - 10
SP - 1
EP - 16
JO - Brain Sciences
JF - Brain Sciences
SN - 2076-3425
IS - 10
M1 - 752
ER -