Early onset epilepsy caused by low-grade epilepsy-associated tumors and focal meningeal involvement

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Low-grade epilepsy-associated neuroepithelial tumors (LEATs) are a frequent etiology in pediatric patients with epilepsy undergoing surgery. Objective: To identify differences in clinical and post-surgical follow-up between patients with focal meningeal involvement (MI) and those without MI within our cohort of pediatric patients with LEATs. Methods: We retrospectively reviewed all pediatric patients (<18 y) who underwent epilepsy surgery between 2011 and 2017 at our hospital. Cohort inclusion required histological diagnosis of LEATs and post-surgical follow-up of ≥2 y We subsequently stratified patients according to presence of neuroradiological MI. Results: We identified 37 patients: five with MI and 32 without. Half of patients (19) were drug sensitive at surgery; similar between groups. The group with MI differed mainly for age of epilepsy-onset (0.6 vs. 7.0 y) but not for epilepsy duration (0.9 vs. 1.5 y). Post-surgery radiological follow-up (median 4.0 y; IQR 2.8–5.0 y) did not indicate disease progression. Seizure outcome was excellent in both groups, with 34 patients overall being both drug-and seizure-free. Conclusions: Our study identified a new subgroup of LEATs with focal MI and excellent post-surgical outcome. Moreover, this highlights the effectiveness of early surgery in pediatric LEATs.

Original languageEnglish
Article number752
Pages (from-to)1-16
Number of pages16
JournalBrain Sciences
Volume10
Issue number10
DOIs
Publication statusPublished - Oct 2020

Keywords

  • Drug resistant epilepsy
  • Epilepsy
  • Meningeal neoplasms
  • Neuroepithelial tumors
  • Pediatrics
  • Surgery
  • Temporal lobe

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Early onset epilepsy caused by low-grade epilepsy-associated tumors and focal meningeal involvement'. Together they form a unique fingerprint.

Cite this