Early onset of lithium prophylaxis as a predictor of good long-term outcome

L. Franchini, R. Zanardi, E. Smeraldi, M. Gasperini

Research output: Contribution to journalArticlepeer-review


The recurrence rates during lithium preventive treatment were investigated in a sample of 270 Mood Disorder subjects subdivided according to their onset time for lithium prophylaxis as very early (within 5 years from the onset of illness), early (6-10 years), late (11-20 years) and very late (more than 21 years). 131 subjects of the sample followed for 4 years prolonged the observation for a further period of 8 years. Results indicated that beginning lithium therapy within the first ten years of illness predicts better preventive outcomes than beginning prophylaxis later, both in major depression, recurrent and bipolar patients.

Original languageEnglish
Pages (from-to)227-230
Number of pages4
JournalEuropean Archives of Psychiatry and Clinical Neuroscience
Issue number5
Publication statusPublished - Oct 1999


  • Lithium salts
  • Prophylactic treatment
  • Recurrence index

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health
  • Neuropsychology and Physiological Psychology

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