Early-onset versus late-onset Crohn’s disease: An Italian cohort study

Laura Cantoro; Marco Vincenzo Lenti; Rita Monterubbianesi; Michele Cicala; Diana Giannarelli; Claudio Papi; Anna Kohn; Antonio Di Sabatino

doi:10.1177/2050640619860661

Early-onset versus late-onset Crohn’s disease: An Italian cohort study

Laura Cantoro, Marco Vincenzo Lenti, Rita Monterubbianesi, Michele Cicala, Diana Giannarelli, Claudio Papi, Anna Kohn, Antonio Di Sabatino

Research output: Contribution to journal › Article › peer-review

Abstract

Background Disease heterogeneity, according to the age at onset, has been reported in Crohn?s disease (CD). Objective This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old. Methods EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period. Results Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7?±?7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p ?

Original language	English
Pages (from-to)	52-58
Number of pages	7
Journal	United Eur. Gastroenterol. J.
Volume	8
Issue number	1
DOIs	https://doi.org/10.1177/2050640619860661
Publication status	Published - 2020

Keywords

Clinical outcomes
Crohn’s disease
inflammatory bowel disease

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title = "Early-onset versus late-onset Crohn{\textquoteright}s disease: An Italian cohort study",

abstract = "Background Disease heterogeneity, according to the age at onset, has been reported in Crohn?s disease (CD). Objective This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old. Methods EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period. Results Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7?±?7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p ?",

keywords = "Clinical outcomes, Crohn{\textquoteright}s disease, inflammatory bowel disease",

author = "Laura Cantoro and Lenti, {Marco Vincenzo} and Rita Monterubbianesi and Michele Cicala and Diana Giannarelli and Claudio Papi and Anna Kohn and {Di Sabatino}, Antonio",

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T1 - Early-onset versus late-onset Crohn’s disease: An Italian cohort study

AU - Cantoro, Laura

AU - Lenti, Marco Vincenzo

AU - Monterubbianesi, Rita

AU - Cicala, Michele

AU - Giannarelli, Diana

AU - Papi, Claudio

AU - Kohn, Anna

AU - Di Sabatino, Antonio

N1 - https://doi.org/10.1177/2050640619860661

PY - 2020

Y1 - 2020

N2 - Background Disease heterogeneity, according to the age at onset, has been reported in Crohn?s disease (CD). Objective This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old. Methods EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period. Results Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7?±?7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p ?

AB - Background Disease heterogeneity, according to the age at onset, has been reported in Crohn?s disease (CD). Objective This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old. Methods EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period. Results Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7?±?7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p ?

KW - Clinical outcomes

KW - Crohn’s disease

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