Early-onset versus late-onset Crohn’s disease: An Italian cohort study

Laura Cantoro, Marco Vincenzo Lenti, Rita Monterubbianesi, Michele Cicala, Diana Giannarelli, Claudio Papi, Anna Kohn, Antonio Di Sabatino

Research output: Contribution to journalArticlepeer-review


Background Disease heterogeneity, according to the age at onset, has been reported in Crohn?s disease (CD). Objective This study aimed to compare natural history in CD patients diagnosed ≤17 (early onset (EO)) versus ≥60 (late onset (LO)) years old. Methods EO CD and LO CD patients referred to two Italian inflammatory bowel disease (IBD) centres were included. Relevant data comprised sex, current smoking, disease location and behaviour, IBD family history, extra-intestinal manifestations and use of medical/surgical therapy during the follow-up period. Results Among 2321 CD patients, 160 met the inclusion criteria: 92 in the EO and 68 in the LO group (mean follow-up 11.7?±?7.7 years). Family history of IBD was more frequent in EO compared to LO CD (26% vs. 4%; p ?
Original languageEnglish
Pages (from-to)52-58
Number of pages7
JournalUnited Eur. Gastroenterol. J.
Issue number1
Publication statusPublished - 2020


  • Clinical outcomes
  • Crohn’s disease
  • inflammatory bowel disease

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