Early outcome of liver transplantation performed with organs procured from brain death donors with transient or sustained cardio-circulatory collapse

F. Valenza, A. Villa, S. Froio, S. Coppola, F. Barretta, E. Melada, S. Gatti, L. Avalli, G. Citerio, G. E. Rossi, L. Gattinoni

Research output: Contribution to journalArticle

Abstract

Background. Aim of this study was to compare early graft function after transplantation of recipients transplanted with livers procured from donors after brain death who experienced transient or sustained cardio-circulatory collapse. Methods. We retrospectively analysed patients who underwent liver transplantation (LTx) at our Institution from January 2010 to May 2012. Recipients were divided into 3 groups: those who received livers from brain death donors who experienced reversible cardio-circulatory arrest before organ procurement (RCA); those who experienced sustained cardio-circulatory collapse, treated with extra-corporeal membrane oxygenation support as rescue therapy of refractory cardiogenic shock (ECMO). Standard donors were considered as reference group (REF). Postoperative graft function, Primary Non-Function (PNF), and complications during the first 30 days were analysed. Results. 102 LTx were analysed (76 REF, 22 RCA and 4 ECMO). The main cause of donor's death was post-anoxic coma in RCA and ECMO, cerebrovascular accident in REF. SGOT in REF, RCA, and ECMO donors were 27 [17- 43], 54 [34-92], 716 [190-962] respectively, SGPT 17 [12-34], 46 [27-73], 84 [51-175] UI/L respectively, both P

Original languageEnglish
Pages (from-to)507-515
Number of pages9
JournalMinerva Anestesiologica
Volume81
Issue number5
Publication statusPublished - May 1 2015

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Keywords

  • Brain death
  • Heart arrest
  • Liver transplantation
  • Risk factors
  • Tissue and organ procurement

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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