Early ovarian cancer: Is there a role for systematic pelvic and para- aortic lymphadenectomy?

G. Baiocchi, F. Raspagliesi, G. Grosso, R. Fontanelli, L. Cobellis, E. Di Re, F. Di Re

Research output: Contribution to journalArticle

Abstract

In order to focus on the incidence and the clinical significance of lymphatic spread in patients with cancer apparently confined to the ovaries, we present our 20 year experience in a large series of patients with early ovarian cancer who had systematic pelvic and para-aortic lymphadenectomy. A retrospective study of 280 consecutive patients is presented. Systematic pelvic and para-aortic lymphadenectomy was performed in 205 cases (73.2%). Selective sampling and node biopsy were performed in 30 (10.7%) and 7 (2.5%), respectively. Node metastases were found in 32/242 patients (13.2%). The incidence of metastatic nodes was significantly higher in patients with serous adenocarcinomas and]or poorly-differentiated tumors. When few nodes were involved (1-3) lymphatic spread was most ipsilateral to the tumor. Even though the retrospective nature of the study has to be considered, univariate analysis revealed statistically significant differences in 5-year survival based on FIGO stage, histology, grade of differentiation, and node status. By contrast, using multivariate analysis, none of these risk factors was an independent variable for predicting long-term survival. However, node status closely approached the statistically significant level (P = 0.06). Only prospective and randomized studies can clarify the role of lymphadenectomy in early ovarian cancer. However, while awaiting these results, this surgical procedure should be a part of a research protocol.

Original languageEnglish
Pages (from-to)103-108
Number of pages6
JournalInternational Journal of Gynecological Cancer
Volume8
Issue number2
DOIs
Publication statusPublished - 1998

Keywords

  • Early ovarian cancer
  • Lymph node status in ovarian cancer
  • Lymphadenectomy in ovarian cancer
  • Ovarian cancer

ASJC Scopus subject areas

  • Cancer Research
  • Obstetrics and Gynaecology
  • Oncology

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