Abstract
Abstract. Therapy‐induced modifications of bone marrow plasma cell kinetics were studied in three patients with myelomatosis. the investigation was performed prior to and 15 d after termination of a course of aggressive chemotherapy. an increase in the labelling index (40‐212% of pretreatment values) with a corresponding reduction of Ts (5‐34%) was observed in all cases. As a consequence of this combined variation, the fractional turnover rate (which represents the percentage of cells produced per unit time) was the parameter with the highest increment (54‐276%). These results indicate that plasma cell recruitment occurs soon after chemotherapy and is characterized by a shorter S phase and a higher number of DNA‐synthesizing cells.
Original language | English |
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Pages (from-to) | 405-409 |
Number of pages | 5 |
Journal | Cell Proliferation |
Volume | 21 |
Issue number | 6 |
DOIs | |
Publication status | Published - 1988 |
ASJC Scopus subject areas
- Cell Biology