Early Postoperative Radiotherapy is Associated with Worse Functional Outcomes in Patients with Prostate Cancer

E Zaffuto, G Gandaglia, Nicola Fossati, P Dell'Oglio, M Moschini, V Cucchiara, N Suardi, Vincenzo Mirone, M Bandini, SF Shariat, PI Karakiewicz, F Montorsi, A Briganti

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Abstract

Purpose The effect of time between radical prostatectomy and radiation therapy on postoperative functional outcomes is still unclear in patients with surgically managed prostate cancer. We hypothesized that a shorter time between radical prostatectomy and radiotherapy might be associated with worse functional recovery rates after radical prostatectomy. Materials and Methods We retrospectively evaluated 2,190 patients treated with radical prostatectomy and stratified according to radiotherapy schedule (adjuvant radiotherapy, salvage radiotherapy, no radiotherapy). We examined recovery rates for erectile function and urinary function according to adjuvant radiotherapy, salvage radiotherapy and no radiotherapy, and according to time from surgery to radiotherapy. Cox regression analyses were used to evaluate the impact of these predictors on functional outcomes. Results Median followup was 48 months. The 3-year erectile function recovery rates were 35.0%, 29.0% and 11.6% in patients who received no radiotherapy, salvage radiotherapy and adjuvant radiotherapy, respectively (p
Original languageEnglish
Pages (from-to)669-675
Number of pages7
JournalJournal of Urology
Volume197
Issue number3
DOIs
Publication statusPublished - 2017

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Prostatic Neoplasms
Radiotherapy
Prostatectomy
Adjuvant Radiotherapy
Recovery of Function
Appointments and Schedules
Regression Analysis

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Early Postoperative Radiotherapy is Associated with Worse Functional Outcomes in Patients with Prostate Cancer. / Zaffuto, E; Gandaglia, G; Fossati, Nicola; Dell'Oglio, P; Moschini, M; Cucchiara, V; Suardi, N; Mirone, Vincenzo; Bandini, M; Shariat, SF; Karakiewicz, PI; Montorsi, F; Briganti, A.

In: Journal of Urology, Vol. 197, No. 3, 2017, p. 669-675.

Research output: Contribution to journalArticle

Zaffuto, E, Gandaglia, G, Fossati, N, Dell'Oglio, P, Moschini, M, Cucchiara, V, Suardi, N, Mirone, V, Bandini, M, Shariat, SF, Karakiewicz, PI, Montorsi, F & Briganti, A 2017, 'Early Postoperative Radiotherapy is Associated with Worse Functional Outcomes in Patients with Prostate Cancer', Journal of Urology, vol. 197, no. 3, pp. 669-675. https://doi.org/10.1016/j.juro.2016.09.079
Zaffuto, E ; Gandaglia, G ; Fossati, Nicola ; Dell'Oglio, P ; Moschini, M ; Cucchiara, V ; Suardi, N ; Mirone, Vincenzo ; Bandini, M ; Shariat, SF ; Karakiewicz, PI ; Montorsi, F ; Briganti, A. / Early Postoperative Radiotherapy is Associated with Worse Functional Outcomes in Patients with Prostate Cancer. In: Journal of Urology. 2017 ; Vol. 197, No. 3. pp. 669-675.
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AU - Zaffuto, E

AU - Gandaglia, G

AU - Fossati, Nicola

AU - Dell'Oglio, P

AU - Moschini, M

AU - Cucchiara, V

AU - Suardi, N

AU - Mirone, Vincenzo

AU - Bandini, M

AU - Shariat, SF

AU - Karakiewicz, PI

AU - Montorsi, F

AU - Briganti, A

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N2 - Purpose The effect of time between radical prostatectomy and radiation therapy on postoperative functional outcomes is still unclear in patients with surgically managed prostate cancer. We hypothesized that a shorter time between radical prostatectomy and radiotherapy might be associated with worse functional recovery rates after radical prostatectomy. Materials and Methods We retrospectively evaluated 2,190 patients treated with radical prostatectomy and stratified according to radiotherapy schedule (adjuvant radiotherapy, salvage radiotherapy, no radiotherapy). We examined recovery rates for erectile function and urinary function according to adjuvant radiotherapy, salvage radiotherapy and no radiotherapy, and according to time from surgery to radiotherapy. Cox regression analyses were used to evaluate the impact of these predictors on functional outcomes. Results Median followup was 48 months. The 3-year erectile function recovery rates were 35.0%, 29.0% and 11.6% in patients who received no radiotherapy, salvage radiotherapy and adjuvant radiotherapy, respectively (p

AB - Purpose The effect of time between radical prostatectomy and radiation therapy on postoperative functional outcomes is still unclear in patients with surgically managed prostate cancer. We hypothesized that a shorter time between radical prostatectomy and radiotherapy might be associated with worse functional recovery rates after radical prostatectomy. Materials and Methods We retrospectively evaluated 2,190 patients treated with radical prostatectomy and stratified according to radiotherapy schedule (adjuvant radiotherapy, salvage radiotherapy, no radiotherapy). We examined recovery rates for erectile function and urinary function according to adjuvant radiotherapy, salvage radiotherapy and no radiotherapy, and according to time from surgery to radiotherapy. Cox regression analyses were used to evaluate the impact of these predictors on functional outcomes. Results Median followup was 48 months. The 3-year erectile function recovery rates were 35.0%, 29.0% and 11.6% in patients who received no radiotherapy, salvage radiotherapy and adjuvant radiotherapy, respectively (p

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