Abstract
Background: We investigated the possible use of clinical signs of chemotherapy-induced peripheral neurotoxicity (CIPN) or of nerve growth factor (NGF) circulating levels to predict the final outcome of CIPN. Patients and methods: Sixty-two women affected by locally advanced squamous cervical carcinoma treated with TP (paclitaxel 175 mg/m2 over a 3 h infusion plus cisplatin 75 mg/m2) or TIP (TP plus ifosphamide 5 mg/m2) were examined and scored according to the Total Neuropathy Score (TNS), before and during chemotherapy. Results: A correlation with the final severity of CIPN was observed with vibration perception and deep tendon reflex evaluation, while pin sensibility, strength, and autonomic symptoms and signs were not informative. A highly significant correlation existed between the decrease in circulating levels of NGF and the severity of CIPN (r=-0.579; P
Original language | English |
---|---|
Pages (from-to) | 1439-1442 |
Number of pages | 4 |
Journal | Annals of Oncology |
Volume | 15 |
Issue number | 9 |
DOIs | |
Publication status | Published - Sep 2004 |
Keywords
- Chemotherapy
- Cisplatin
- Neuropathy
- Paclitaxel
ASJC Scopus subject areas
- Oncology
- Cancer Research