Early predictors of peripheral neurotoxicity in cisplatin and paclitaxel combination chemotherapy

Guido Cavaletti, G. Bogliun, L. Marzorati, A. Zincone, M. Piatti, N. Colombo, D. Franchi, M. T. La Presa, A. Lissoni, A. Buda, F. Fei, S. Cundari, C. Zanna

Research output: Contribution to journalArticlepeer-review


Background: We investigated the possible use of clinical signs of chemotherapy-induced peripheral neurotoxicity (CIPN) or of nerve growth factor (NGF) circulating levels to predict the final outcome of CIPN. Patients and methods: Sixty-two women affected by locally advanced squamous cervical carcinoma treated with TP (paclitaxel 175 mg/m2 over a 3 h infusion plus cisplatin 75 mg/m2) or TIP (TP plus ifosphamide 5 mg/m2) were examined and scored according to the Total Neuropathy Score (TNS), before and during chemotherapy. Results: A correlation with the final severity of CIPN was observed with vibration perception and deep tendon reflex evaluation, while pin sensibility, strength, and autonomic symptoms and signs were not informative. A highly significant correlation existed between the decrease in circulating levels of NGF and the severity of CIPN (r=-0.579; P

Original languageEnglish
Pages (from-to)1439-1442
Number of pages4
JournalAnnals of Oncology
Issue number9
Publication statusPublished - Sep 2004


  • Chemotherapy
  • Cisplatin
  • Neuropathy
  • Paclitaxel

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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