Abstract
A multicenter prospective investigation was conducted in 17 teaching and general hospital in Italy to assess the efficacy of the care delivered to previously untreated patients with epilepsy. 175 cases were included and allocated to monotherapy. Only 112 cases completed the first year of follow-up. Of these, 59 (52.7%) were completely controlled and 53 (47.3%) had one or more seizure relapses. Controlied and uncontrolled patients were compared with respect to the main variables believed to influence non-responsiveness to standard therapy. The proportion of cases with relapses was significantly associated with the number of seizures reported before treatment was started. Selected seizure patterns (absences, myoclonic seizures) and prolonged disease duration were also reported more frequently among patients with recurrences. The implications of these findings are discussed with respect to drug response and prognosis of epilepsy.
| Original language | English |
|---|---|
| Pages (from-to) | 421-429 |
| Number of pages | 9 |
| Journal | Italian Journal of Neurological Sciences |
| Volume | 7 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - Jul 1986 |
Fingerprint
Keywords
- Epidemiology
- epilepsy
- monotherapy
- prognosis
ASJC Scopus subject areas
- Neuroscience(all)
- Clinical Neurology
Cite this
Early prognosis of epilepsy. Effects of treatment in the first follow-up year. / Di Mascio, R.; Beghi, E.; Sasanelli, F.; Tognoni, G.
In: Italian Journal of Neurological Sciences, Vol. 7, No. 4, 07.1986, p. 421-429.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early prognosis of epilepsy. Effects of treatment in the first follow-up year
AU - Di Mascio, R.
AU - Beghi, E.
AU - Sasanelli, F.
AU - Tognoni, G.
PY - 1986/7
Y1 - 1986/7
N2 - A multicenter prospective investigation was conducted in 17 teaching and general hospital in Italy to assess the efficacy of the care delivered to previously untreated patients with epilepsy. 175 cases were included and allocated to monotherapy. Only 112 cases completed the first year of follow-up. Of these, 59 (52.7%) were completely controlled and 53 (47.3%) had one or more seizure relapses. Controlied and uncontrolled patients were compared with respect to the main variables believed to influence non-responsiveness to standard therapy. The proportion of cases with relapses was significantly associated with the number of seizures reported before treatment was started. Selected seizure patterns (absences, myoclonic seizures) and prolonged disease duration were also reported more frequently among patients with recurrences. The implications of these findings are discussed with respect to drug response and prognosis of epilepsy.
AB - A multicenter prospective investigation was conducted in 17 teaching and general hospital in Italy to assess the efficacy of the care delivered to previously untreated patients with epilepsy. 175 cases were included and allocated to monotherapy. Only 112 cases completed the first year of follow-up. Of these, 59 (52.7%) were completely controlled and 53 (47.3%) had one or more seizure relapses. Controlied and uncontrolled patients were compared with respect to the main variables believed to influence non-responsiveness to standard therapy. The proportion of cases with relapses was significantly associated with the number of seizures reported before treatment was started. Selected seizure patterns (absences, myoclonic seizures) and prolonged disease duration were also reported more frequently among patients with recurrences. The implications of these findings are discussed with respect to drug response and prognosis of epilepsy.
KW - Epidemiology
KW - epilepsy
KW - monotherapy
KW - prognosis
UR - http://www.scopus.com/inward/record.url?scp=0022458381&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0022458381&partnerID=8YFLogxK
U2 - 10.1007/BF02283020
DO - 10.1007/BF02283020
M3 - Article
C2 - 3759415
AN - SCOPUS:0022458381
VL - 7
SP - 421
EP - 429
JO - Italian Journal of Neurological Sciences
JF - Italian Journal of Neurological Sciences
SN - 0392-0461
IS - 4
ER -