Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study.: Transplant international : official journal of the European Society for Organ Transplantation

Jacopo Fumagalli; Lorenzo Rosso; Francesca Gori; Letizia Corinna Morlacchi; Valeria Rossetti; Paolo Tarsia; Francesco Blasi; Ilaria Righi; Paolo Mendogni; Alessandro Palleschi; Davide Tosi; Gianluca Bonitta; Mario Nosotti; Elena Benazzi; Vittorio Scaravilli; Franco Valenza; Giacomo Grasselli; Alberto Zanella

doi:10.1111/tri.13606

Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation

Jacopo Fumagalli, Lorenzo Rosso, Francesca Gori, Letizia Corinna Morlacchi, Valeria Rossetti, Paolo Tarsia, Francesco Blasi, Ilaria Righi, Paolo Mendogni, Alessandro Palleschi, Davide Tosi, Gianluca Bonitta, Mario Nosotti, Elena Benazzi, Vittorio Scaravilli, Franco Valenza, Giacomo Grasselli, Alberto Zanella

Research output: Contribution to journal › Article › peer-review

Abstract

Outcomes after transplantation of lungs (LuTX) treated with ex-vivo lung perfusion (EVLP) are debated. In a single-center 8 years of retrospective analysis, we compared: donors' and recipients' characteristics, gas exchange and lung mechanics at ICU admission, 3, 6, and 12 months, and patients' survival of LuTX from standard donors compared with EVLP-treated grafts. A total of 193 LuTX were performed. Thirty-one LuTX, out of 50 EVLP procedures, were carried out: 7 from nonheart beating and 24 from extended criteria brain-dead donors. Recipients' characteristics were similar. At ICU admission, compared with standard donors, EVLP patients had worse PaO(2) /FiO(2) [276 (206; 374) vs. 204 (133; 245) mmHg, P

Original language	English
Pages (from-to)	773-785
Number of pages	13
Journal	Transplant International
Volume	33
Issue number	7
DOIs	https://doi.org/10.1111/tri.13606
Publication status	Published - 2020

Keywords

ex-vivo lung perfusion
lung transplantation

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10.1111/tri.13606

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Fumagalli, J., Rosso, L., Gori, F., Morlacchi, L. C., Rossetti, V., Tarsia, P., Blasi, F., Righi, I., Mendogni, P., Palleschi, A., Tosi, D., Bonitta, G., Nosotti, M., Benazzi, E., Scaravilli, V., Valenza, F., Grasselli, G., & Zanella, A. (2020). Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation. Transplant International, 33(7), 773-785. https://doi.org/10.1111/tri.13606

Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation. / Fumagalli, Jacopo; Rosso, Lorenzo ; Gori, Francesca ; Morlacchi, Letizia Corinna ; Rossetti, Valeria; Tarsia, Paolo; Blasi, Francesco ; Righi, Ilaria ; Mendogni, Paolo ; Palleschi, Alessandro ; Tosi, Davide; Bonitta, Gianluca; Nosotti, Mario; Benazzi, Elena; Scaravilli, Vittorio ; Valenza, Franco ; Grasselli, Giacomo ; Zanella, Alberto.

In: Transplant International, Vol. 33, No. 7, 2020, p. 773-785.

Research output: Contribution to journal › Article › peer-review

Fumagalli, J, Rosso, L , Gori, F , Morlacchi, LC , Rossetti, V, Tarsia, P, Blasi, F , Righi, I , Mendogni, P , Palleschi, A , Tosi, D, Bonitta, G, Nosotti, M, Benazzi, E, Scaravilli, V , Valenza, F , Grasselli, G & Zanella, A 2020, 'Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation', Transplant International, vol. 33, no. 7, pp. 773-785. https://doi.org/10.1111/tri.13606

Fumagalli J, Rosso L , Gori F , Morlacchi LC , Rossetti V, Tarsia P et al. Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation. Transplant International. 2020;33(7):773-785. https://doi.org/10.1111/tri.13606

Fumagalli, Jacopo ; Rosso, Lorenzo ; Gori, Francesca ; Morlacchi, Letizia Corinna ; Rossetti, Valeria ; Tarsia, Paolo ; Blasi, Francesco ; Righi, Ilaria ; Mendogni, Paolo ; Palleschi, Alessandro ; Tosi, Davide ; Bonitta, Gianluca ; Nosotti, Mario ; Benazzi, Elena ; Scaravilli, Vittorio ; Valenza, Franco ; Grasselli, Giacomo ; Zanella, Alberto. / Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation. In: Transplant International. 2020 ; Vol. 33, No. 7. pp. 773-785.

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abstract = "Outcomes after transplantation of lungs (LuTX) treated with ex-vivo lung perfusion (EVLP) are debated. In a single-center 8 years of retrospective analysis, we compared: donors' and recipients' characteristics, gas exchange and lung mechanics at ICU admission, 3, 6, and 12 months, and patients' survival of LuTX from standard donors compared with EVLP-treated grafts. A total of 193 LuTX were performed. Thirty-one LuTX, out of 50 EVLP procedures, were carried out: 7 from nonheart beating and 24 from extended criteria brain-dead donors. Recipients' characteristics were similar. At ICU admission, compared with standard donors, EVLP patients had worse PaO(2) /FiO(2) [276 (206; 374) vs. 204 (133; 245) mmHg, P ",

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