Early pulmonary function and mid-term outcome in lung transplantation after ex-vivo lung perfusion - a single-center, retrospective, observational, cohort study. Transplant international : official journal of the European Society for Organ Transplantation

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Abstract

Outcomes after transplantation of lungs (LuTX) treated with ex-vivo lung perfusion (EVLP) are debated. In a single-center 8 years of retrospective analysis, we compared: donors' and recipients' characteristics, gas exchange and lung mechanics at ICU admission, 3, 6, and 12 months, and patients' survival of LuTX from standard donors compared with EVLP-treated grafts. A total of 193 LuTX were performed. Thirty-one LuTX, out of 50 EVLP procedures, were carried out: 7 from nonheart beating and 24 from extended criteria brain-dead donors. Recipients' characteristics were similar. At ICU admission, compared with standard donors, EVLP patients had worse PaO(2) /FiO(2) [276 (206; 374) vs. 204 (133; 245) mmHg, P 
Original languageEnglish
Pages (from-to)773-785
Number of pages13
JournalTransplant International
Volume33
Issue number7
DOIs
Publication statusPublished - 2020

Keywords

  • ex-vivo lung perfusion
  • lung transplantation

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