Early retinol-binding protein levels are associated with growth changes in infants born to diabetic mothers

G. Francescato, M. Agosti, G. Bedogni, E. Pastò, G. Melzi D'Eril, A. Barassi, P. Risè, C. Agostoni

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Biochemical predictors of infants' growth changes are not available. Objectives: We tested whether retinol-binding protein (RBP), docosahexaenoic acid and insulin (I) measured within 72 h from birth are associated with growth changes in infants born to mothers with gestational diabetes mellitus (GDM). Methods: Fifty-six children, 32 born to diabetic mothers treated with insulin (GDM-I) and 24 born to diabetic mothers treated with diet (GDM-D), were evaluated at 0, 1, 3, 6 and 12 months of life. Results: At multivariable regression performed using generalized estimating equations, early RBP levels and maternal body mass index were associated to average weight changes and early RBP and insulin levels to average length changes, respectively. There was no difference between GDM-I and GDM-D infants. Conclusions: This exploratory study suggests that early RBP levels may be a predictor of growth changes.

Original languageEnglish
JournalPediatric obesity
Volume7
Issue number6
DOIs
Publication statusPublished - Dec 2012

Keywords

  • Docosahexaenoic acid
  • Gestational diabetes
  • Growth
  • Retinol-binding protein

ASJC Scopus subject areas

  • Health Policy
  • Pediatrics, Perinatology, and Child Health
  • Public Health, Environmental and Occupational Health
  • Nutrition and Dietetics

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