Abstract
Context Depending on the pathologic tumour stage, up to 60% of prostate cancer patients who undergo radical prostatectomy will develop biochemical relapse and require further local treatment. Objectives We reviewed the results of early salvage radiation therapy (RT), defined as prostate-specific antigen (PSA) values prior to RT <0.5 ng/ml in the setting of lymph node-negative disease. Evidence acquisition Ten retrospective studies, including one multicentre analysis, were used for this analysis. Among them, we received previously unpublished patient characteristics and updated outcome data from five retrospective single-centre trials to perform a subgroup analysis for early salvage RT. Evidence synthesis Patients treated with early salvage RT have a significantly improved biochemical recurrence-free survival (BRFS) rate compared with those receiving salvage RT initiated after PSA values are >0.5 ng/ml. Similarly, within the cohort of patients with pre-RT PSA values 0.5 ng/ml. Whether the routine application of early salvage RT in patients with initially undetectable PSA levels will be associated with demonstrable clinical benefit awaits the results of ongoing prospective trials.
| Original language | English |
|---|---|
| Pages (from-to) | 1034-1043 |
| Number of pages | 10 |
| Journal | European Urology |
| Volume | 65 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2014 |
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Keywords
- Biochemical recurrence-free survival
- Early salvage radiotherapy
- Prostate cancer
- Radiotherapy
ASJC Scopus subject areas
- Urology
- Medicine(all)
Cite this
Early salvage radiotherapy following radical prostatectomy. / Pfister, David; Bolla, Michel; Briganti, Alberto; Carroll, Peter; Cozzarini, Cesare; Joniau, Steven; Van Poppel, Hein; Roach, Mack; Stephenson, Andrew; Wiegel, Thomas; Zelefsky, Michael J.
In: European Urology, Vol. 65, No. 6, 2014, p. 1034-1043.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early salvage radiotherapy following radical prostatectomy
AU - Pfister, David
AU - Bolla, Michel
AU - Briganti, Alberto
AU - Carroll, Peter
AU - Cozzarini, Cesare
AU - Joniau, Steven
AU - Van Poppel, Hein
AU - Roach, Mack
AU - Stephenson, Andrew
AU - Wiegel, Thomas
AU - Zelefsky, Michael J.
PY - 2014
Y1 - 2014
N2 - Context Depending on the pathologic tumour stage, up to 60% of prostate cancer patients who undergo radical prostatectomy will develop biochemical relapse and require further local treatment. Objectives We reviewed the results of early salvage radiation therapy (RT), defined as prostate-specific antigen (PSA) values prior to RT <0.5 ng/ml in the setting of lymph node-negative disease. Evidence acquisition Ten retrospective studies, including one multicentre analysis, were used for this analysis. Among them, we received previously unpublished patient characteristics and updated outcome data from five retrospective single-centre trials to perform a subgroup analysis for early salvage RT. Evidence synthesis Patients treated with early salvage RT have a significantly improved biochemical recurrence-free survival (BRFS) rate compared with those receiving salvage RT initiated after PSA values are >0.5 ng/ml. Similarly, within the cohort of patients with pre-RT PSA values 0.5 ng/ml. Whether the routine application of early salvage RT in patients with initially undetectable PSA levels will be associated with demonstrable clinical benefit awaits the results of ongoing prospective trials.
AB - Context Depending on the pathologic tumour stage, up to 60% of prostate cancer patients who undergo radical prostatectomy will develop biochemical relapse and require further local treatment. Objectives We reviewed the results of early salvage radiation therapy (RT), defined as prostate-specific antigen (PSA) values prior to RT <0.5 ng/ml in the setting of lymph node-negative disease. Evidence acquisition Ten retrospective studies, including one multicentre analysis, were used for this analysis. Among them, we received previously unpublished patient characteristics and updated outcome data from five retrospective single-centre trials to perform a subgroup analysis for early salvage RT. Evidence synthesis Patients treated with early salvage RT have a significantly improved biochemical recurrence-free survival (BRFS) rate compared with those receiving salvage RT initiated after PSA values are >0.5 ng/ml. Similarly, within the cohort of patients with pre-RT PSA values 0.5 ng/ml. Whether the routine application of early salvage RT in patients with initially undetectable PSA levels will be associated with demonstrable clinical benefit awaits the results of ongoing prospective trials.
KW - Biochemical recurrence-free survival
KW - Early salvage radiotherapy
KW - Prostate cancer
KW - Radiotherapy
UR - http://www.scopus.com/inward/record.url?scp=84899584952&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84899584952&partnerID=8YFLogxK
U2 - 10.1016/j.eururo.2013.08.013
DO - 10.1016/j.eururo.2013.08.013
M3 - Article
C2 - 23972524
AN - SCOPUS:84899584952
VL - 65
SP - 1034
EP - 1043
JO - European Urology
JF - European Urology
SN - 0302-2838
IS - 6
ER -