Early screening for fetal cardiac anomalies by transvaginal echocardiography in an unselected population: The role of operator experience

M. A. Rustico, A. Benettoni, G. D'Ottavio, L. Fischer-Tamaro, G. C. Conoscenti, Y. Meir, R. Natale, R. Bussani, G. P. Mandruzzato

Research output: Contribution to journalArticle

Abstract

Objectives: To examine the accuracy of early transvaginal fetal echocardiography performed in an unselected population by operators with different levels of experience and to compare the results with those obtained from a referral population. Design: Prospective study. Methods: A series of 4785 unselected fetuses and 221 referred fetuses were screened at 13-15 weeks' gestational age by transvaginal echocardiograpby. For each fetus, visualization of the four-chamber view plus the origin of the great arteries was attempted. Color Doppler imaging was only performed in cases of cardiac malformations already identified by two-dimensional echocardiography. The scans were performed by seven operators with different levels of experience. Reliability was assessed by conventional transabdominal echocardiography at 20-22 weeks, by postnatal follow-up in the first 3 months of life, and/or by autopsy in all cases of termination or fetal death. Results: The rate of complete visualization (four-chamber view plus great arteries) was 47.5% in the unselected population, and 76.9% in the referral population. There were four (0.08%) true positives among the unselected fetuses, and five (2.3%) among referrals, mostly with enlarged nuchal translucency or other malformations. Among the unselected fetuses, nine false negatives were detected by transabdominal echocardiography. Improvement in the operators' ability to recognize cardiac anomalies in unselected population was disappointing and was influenced more by individual approach than by the number of examinations performed. Conclusions: Early screening for cardiac anomalies among unselected fetuses is ill-advisable. The usefulness of an early approach is confirmed in high risk fetuses or in the presence of enlarged nuchal translucency when performed by expert operators.

Original languageEnglish
Pages (from-to)614-619
Number of pages6
JournalUltrasound in Obstetrics and Gynecology
Volume16
Issue number7
DOIs
Publication statusPublished - 2000

Fingerprint

echocardiography
fetuses
Echocardiography
Fetus
screening
anomalies
operators
Population
Nuchal Translucency Measurement
Referral and Consultation
arteries
Arteries
chambers
autopsies
Fetal Death
death
Gestational Age
Autopsy
Color
examination

Keywords

  • Early screening
  • Fetal echocardiography
  • Nuchal translucency
  • Operator experience

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology
  • Reproductive Medicine
  • Acoustics and Ultrasonics

Cite this

Early screening for fetal cardiac anomalies by transvaginal echocardiography in an unselected population : The role of operator experience. / Rustico, M. A.; Benettoni, A.; D'Ottavio, G.; Fischer-Tamaro, L.; Conoscenti, G. C.; Meir, Y.; Natale, R.; Bussani, R.; Mandruzzato, G. P.

In: Ultrasound in Obstetrics and Gynecology, Vol. 16, No. 7, 2000, p. 614-619.

Research output: Contribution to journalArticle

Rustico, MA, Benettoni, A, D'Ottavio, G, Fischer-Tamaro, L, Conoscenti, GC, Meir, Y, Natale, R, Bussani, R & Mandruzzato, GP 2000, 'Early screening for fetal cardiac anomalies by transvaginal echocardiography in an unselected population: The role of operator experience', Ultrasound in Obstetrics and Gynecology, vol. 16, no. 7, pp. 614-619. https://doi.org/10.1046/j.1469-0705.2000.00291.x
Rustico, M. A. ; Benettoni, A. ; D'Ottavio, G. ; Fischer-Tamaro, L. ; Conoscenti, G. C. ; Meir, Y. ; Natale, R. ; Bussani, R. ; Mandruzzato, G. P. / Early screening for fetal cardiac anomalies by transvaginal echocardiography in an unselected population : The role of operator experience. In: Ultrasound in Obstetrics and Gynecology. 2000 ; Vol. 16, No. 7. pp. 614-619.
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AU - Rustico, M. A.

AU - Benettoni, A.

AU - D'Ottavio, G.

AU - Fischer-Tamaro, L.

AU - Conoscenti, G. C.

AU - Meir, Y.

AU - Natale, R.

AU - Bussani, R.

AU - Mandruzzato, G. P.

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N2 - Objectives: To examine the accuracy of early transvaginal fetal echocardiography performed in an unselected population by operators with different levels of experience and to compare the results with those obtained from a referral population. Design: Prospective study. Methods: A series of 4785 unselected fetuses and 221 referred fetuses were screened at 13-15 weeks' gestational age by transvaginal echocardiograpby. For each fetus, visualization of the four-chamber view plus the origin of the great arteries was attempted. Color Doppler imaging was only performed in cases of cardiac malformations already identified by two-dimensional echocardiography. The scans were performed by seven operators with different levels of experience. Reliability was assessed by conventional transabdominal echocardiography at 20-22 weeks, by postnatal follow-up in the first 3 months of life, and/or by autopsy in all cases of termination or fetal death. Results: The rate of complete visualization (four-chamber view plus great arteries) was 47.5% in the unselected population, and 76.9% in the referral population. There were four (0.08%) true positives among the unselected fetuses, and five (2.3%) among referrals, mostly with enlarged nuchal translucency or other malformations. Among the unselected fetuses, nine false negatives were detected by transabdominal echocardiography. Improvement in the operators' ability to recognize cardiac anomalies in unselected population was disappointing and was influenced more by individual approach than by the number of examinations performed. Conclusions: Early screening for cardiac anomalies among unselected fetuses is ill-advisable. The usefulness of an early approach is confirmed in high risk fetuses or in the presence of enlarged nuchal translucency when performed by expert operators.

AB - Objectives: To examine the accuracy of early transvaginal fetal echocardiography performed in an unselected population by operators with different levels of experience and to compare the results with those obtained from a referral population. Design: Prospective study. Methods: A series of 4785 unselected fetuses and 221 referred fetuses were screened at 13-15 weeks' gestational age by transvaginal echocardiograpby. For each fetus, visualization of the four-chamber view plus the origin of the great arteries was attempted. Color Doppler imaging was only performed in cases of cardiac malformations already identified by two-dimensional echocardiography. The scans were performed by seven operators with different levels of experience. Reliability was assessed by conventional transabdominal echocardiography at 20-22 weeks, by postnatal follow-up in the first 3 months of life, and/or by autopsy in all cases of termination or fetal death. Results: The rate of complete visualization (four-chamber view plus great arteries) was 47.5% in the unselected population, and 76.9% in the referral population. There were four (0.08%) true positives among the unselected fetuses, and five (2.3%) among referrals, mostly with enlarged nuchal translucency or other malformations. Among the unselected fetuses, nine false negatives were detected by transabdominal echocardiography. Improvement in the operators' ability to recognize cardiac anomalies in unselected population was disappointing and was influenced more by individual approach than by the number of examinations performed. Conclusions: Early screening for cardiac anomalies among unselected fetuses is ill-advisable. The usefulness of an early approach is confirmed in high risk fetuses or in the presence of enlarged nuchal translucency when performed by expert operators.

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