TY - JOUR
T1 - Early stage gastric diffuse large B-cell lymphomas
T2 - Results of a randomised trial comparing chemotherapy alone versus chemotherapy + involved field radiotherapy
AU - Martinelli, Giovanni
AU - Gigli, Federica
AU - Calabrese, Liliana
AU - Ferrucci, Pier Francesco
AU - Zucca, Emanuele
AU - Crosta, Cristiano
AU - Pruneri, Giancarlo
AU - Preda, Lorenzo
AU - Piperno, Gaia
AU - Gospodarowicz, Mary
AU - Cavalli, Francesco
AU - Gomez, Henry Moreno
PY - 2009
Y1 - 2009
N2 - Here, we present the results of a randomised clinical trial carried out between 1998 and 2004, evaluating the possible role of radiotherapy (RT) as consolidation treatment after induction chemotherapy (CT) in diffuse large B-cell (DLBC) gastric lymphoma. Fifty-four patients were enrolled and all received anthracycline containing regimens as induction CT. Patients were evaluated after four to six cycles and those in complete remission (CR) were randomised to receive gastric involved field (IF) RT or two addition cycles of the same CT. Forty-five patients (83%) were randomised after the induction CT. Clinical results of patients allocated to the RT arm showed a significant reduction in incidence of local relapse versus patients who received CT alone. However, overall survival was not different between the two arms. Our results confirm that CT could be considered as first line therapy for newly diagnosed gastric DLBC lymphoma; IF RT delivered in those patients achieving CR after induction CT is able to prevent local relapse.
AB - Here, we present the results of a randomised clinical trial carried out between 1998 and 2004, evaluating the possible role of radiotherapy (RT) as consolidation treatment after induction chemotherapy (CT) in diffuse large B-cell (DLBC) gastric lymphoma. Fifty-four patients were enrolled and all received anthracycline containing regimens as induction CT. Patients were evaluated after four to six cycles and those in complete remission (CR) were randomised to receive gastric involved field (IF) RT or two addition cycles of the same CT. Forty-five patients (83%) were randomised after the induction CT. Clinical results of patients allocated to the RT arm showed a significant reduction in incidence of local relapse versus patients who received CT alone. However, overall survival was not different between the two arms. Our results confirm that CT could be considered as first line therapy for newly diagnosed gastric DLBC lymphoma; IF RT delivered in those patients achieving CR after induction CT is able to prevent local relapse.
KW - Diffuse large B-cell lymphoma
KW - Gastric lymphoma
KW - Involved field radiotherapy
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U2 - 10.1080/10428190902912478
DO - 10.1080/10428190902912478
M3 - Article
C2 - 19479614
AN - SCOPUS:68449101743
VL - 50
SP - 925
EP - 931
JO - Leukemia and Lymphoma
JF - Leukemia and Lymphoma
SN - 1042-8194
IS - 6
ER -