Abstract
The early stages of behavioral variant frontotemporal dementia (bvFTD) are still not completely characterized. In a consecutive series of patients with probable bvFTD diagnosis confirmed by follow-up, we retrospectively evaluated the features at onset. Patients were reclassified according to presenting features and current diagnostic criteria into probable and possible bvFTD. The term "pre-bvFTD" was adopted for patients with cognitive and/or behavioral impairment not fulfilling bvFTD criteria and no deficits in activities of daily living. One hundred ninety-four subjects were included; at first visit, 70% (n = 136) patients were already classified as probable bvFTD. Of the remaining 30% (n = 58), 60% fulfilled criteria for possible bvFTD, while 40% did not, and were classified as pre-FTD. The neuropsychological pattern in possible bvFTD and pre-bvFTD was similar, although possible bvFTD showed more behavioral abnormalities. Pre-bvFTD subjects had frontotemporal gray matter atrophy, although less extensive than possible bvFTD. Conclusively, most bvFTD patients fulfill current diagnostic criteria at first admission, whereas a relatively small group is characterized by mild behavioral and/or cognitive abnormalities in spite of frontotemporal gray matter atrophy. Our preliminary findings will require a validation in prospective studies involving larger samples of patients.
| Original language | English |
|---|---|
| Pages (from-to) | 3108-3115 |
| Number of pages | 8 |
| Journal | Neurobiology of Aging |
| Volume | 36 |
| Issue number | 11 |
| DOIs | |
| Publication status | Published - Nov 1 2015 |
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Keywords
- Behavioral impairment
- Behavioral variant frontotemporal dementia (bvFTD)
- Frontotemporal dementia
- Mild cognitive impairment (MCI)
- MRI
- Pre-bvFTD
- Prodromal
ASJC Scopus subject areas
- Clinical Neurology
- Neuroscience(all)
- Ageing
- Developmental Biology
- Geriatrics and Gerontology
Cite this
Early stage of behavioral variant frontotemporal dementia : Clinical and neuroimaging correlates. / Borroni, Barbara; Cosseddu, Maura; Pilotto, Andrea; Premi, Enrico; Archetti, Silvana; Gasparotti, Roberto; Cappa, Stefano; Padovani, Alessandro.
In: Neurobiology of Aging, Vol. 36, No. 11, 01.11.2015, p. 3108-3115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Early stage of behavioral variant frontotemporal dementia
T2 - Clinical and neuroimaging correlates
AU - Borroni, Barbara
AU - Cosseddu, Maura
AU - Pilotto, Andrea
AU - Premi, Enrico
AU - Archetti, Silvana
AU - Gasparotti, Roberto
AU - Cappa, Stefano
AU - Padovani, Alessandro
PY - 2015/11/1
Y1 - 2015/11/1
N2 - The early stages of behavioral variant frontotemporal dementia (bvFTD) are still not completely characterized. In a consecutive series of patients with probable bvFTD diagnosis confirmed by follow-up, we retrospectively evaluated the features at onset. Patients were reclassified according to presenting features and current diagnostic criteria into probable and possible bvFTD. The term "pre-bvFTD" was adopted for patients with cognitive and/or behavioral impairment not fulfilling bvFTD criteria and no deficits in activities of daily living. One hundred ninety-four subjects were included; at first visit, 70% (n = 136) patients were already classified as probable bvFTD. Of the remaining 30% (n = 58), 60% fulfilled criteria for possible bvFTD, while 40% did not, and were classified as pre-FTD. The neuropsychological pattern in possible bvFTD and pre-bvFTD was similar, although possible bvFTD showed more behavioral abnormalities. Pre-bvFTD subjects had frontotemporal gray matter atrophy, although less extensive than possible bvFTD. Conclusively, most bvFTD patients fulfill current diagnostic criteria at first admission, whereas a relatively small group is characterized by mild behavioral and/or cognitive abnormalities in spite of frontotemporal gray matter atrophy. Our preliminary findings will require a validation in prospective studies involving larger samples of patients.
AB - The early stages of behavioral variant frontotemporal dementia (bvFTD) are still not completely characterized. In a consecutive series of patients with probable bvFTD diagnosis confirmed by follow-up, we retrospectively evaluated the features at onset. Patients were reclassified according to presenting features and current diagnostic criteria into probable and possible bvFTD. The term "pre-bvFTD" was adopted for patients with cognitive and/or behavioral impairment not fulfilling bvFTD criteria and no deficits in activities of daily living. One hundred ninety-four subjects were included; at first visit, 70% (n = 136) patients were already classified as probable bvFTD. Of the remaining 30% (n = 58), 60% fulfilled criteria for possible bvFTD, while 40% did not, and were classified as pre-FTD. The neuropsychological pattern in possible bvFTD and pre-bvFTD was similar, although possible bvFTD showed more behavioral abnormalities. Pre-bvFTD subjects had frontotemporal gray matter atrophy, although less extensive than possible bvFTD. Conclusively, most bvFTD patients fulfill current diagnostic criteria at first admission, whereas a relatively small group is characterized by mild behavioral and/or cognitive abnormalities in spite of frontotemporal gray matter atrophy. Our preliminary findings will require a validation in prospective studies involving larger samples of patients.
KW - Behavioral impairment
KW - Behavioral variant frontotemporal dementia (bvFTD)
KW - Frontotemporal dementia
KW - Mild cognitive impairment (MCI)
KW - MRI
KW - Pre-bvFTD
KW - Prodromal
UR - http://www.scopus.com/inward/record.url?scp=84947017578&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84947017578&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2015.07.019
DO - 10.1016/j.neurobiolaging.2015.07.019
M3 - Article
VL - 36
SP - 3108
EP - 3115
JO - Neurobiology of Aging
JF - Neurobiology of Aging
SN - 0197-4580
IS - 11
ER -