Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

B. Borroni, F. Colciaghi, P. Corsini, N. Akkawi, L. Rozzini, E. Del Zotto, G. Talarico, F. Cattabeni, G. L. Lenzi, M. Di Luca, A. Padovani

Research output: Contribution to journalArticlepeer-review

Abstract

Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalNeurological Sciences
Volume23
Issue number5
DOIs
Publication statusPublished - Dec 2002

Keywords

  • Amyloid precursor protein
  • Diagnosis
  • Early stage Alzheimer disease
  • Platelets

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Fingerprint

Dive into the research topics of 'Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms'. Together they form a unique fingerprint.

Cite this