Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

B. Borroni, F. Colciaghi, P. Corsini, N. Akkawi, L. Rozzini, E. Del Zotto, G. Talarico, F. Cattabeni, G. L. Lenzi, M. Di Luca, A. Padovani

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p

Original languageEnglish
Pages (from-to)207-210
Number of pages4
JournalNeurological Sciences
Volume23
Issue number5
DOIs
Publication statusPublished - Dec 2002

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Amyloid beta-Protein Precursor
Alzheimer Disease
Blood Platelets
Dementia
Healthy Volunteers

Keywords

  • Amyloid precursor protein
  • Diagnosis
  • Early stage Alzheimer disease
  • Platelets

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Borroni, B., Colciaghi, F., Corsini, P., Akkawi, N., Rozzini, L., Del Zotto, E., ... Padovani, A. (2002). Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms. Neurological Sciences, 23(5), 207-210. https://doi.org/10.1007/s100720200042

Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms. / Borroni, B.; Colciaghi, F.; Corsini, P.; Akkawi, N.; Rozzini, L.; Del Zotto, E.; Talarico, G.; Cattabeni, F.; Lenzi, G. L.; Di Luca, M.; Padovani, A.

In: Neurological Sciences, Vol. 23, No. 5, 12.2002, p. 207-210.

Research output: Contribution to journalArticle

Borroni, B, Colciaghi, F, Corsini, P, Akkawi, N, Rozzini, L, Del Zotto, E, Talarico, G, Cattabeni, F, Lenzi, GL, Di Luca, M & Padovani, A 2002, 'Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms', Neurological Sciences, vol. 23, no. 5, pp. 207-210. https://doi.org/10.1007/s100720200042
Borroni, B. ; Colciaghi, F. ; Corsini, P. ; Akkawi, N. ; Rozzini, L. ; Del Zotto, E. ; Talarico, G. ; Cattabeni, F. ; Lenzi, G. L. ; Di Luca, M. ; Padovani, A. / Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms. In: Neurological Sciences. 2002 ; Vol. 23, No. 5. pp. 207-210.
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