Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

B. Borroni; F. Colciaghi; P. Corsini; N. Akkawi; L. Rozzini; E. Del Zotto; G. Talarico; F. Cattabeni; G. L. Lenzi; M. Di Luca; A. Padovani

doi:10.1007/s100720200042

Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

B. Borroni, F. Colciaghi, P. Corsini, N. Akkawi, L. Rozzini, E. Del Zotto, G. Talarico, F. Cattabeni, G. L. Lenzi, M. Di Luca, A. Padovani

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p

Original language	English
Pages (from-to)	207-210
Number of pages	4
Journal	Neurological Sciences
Volume	23
Issue number	5
DOIs	https://doi.org/10.1007/s100720200042
Publication status	Published - Dec 2002

Keywords

Amyloid precursor protein
Diagnosis
Early stage Alzheimer disease
Platelets

ASJC Scopus subject areas

Neuroscience(all)
Clinical Neurology

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10.1007/s100720200042

Cite this

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abstract = "Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p",

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T1 - Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

AU - Borroni, B.

AU - Colciaghi, F.

AU - Corsini, P.

AU - Akkawi, N.

AU - Rozzini, L.

AU - Del Zotto, E.

AU - Talarico, G.

AU - Cattabeni, F.

AU - Lenzi, G. L.

AU - Di Luca, M.

AU - Padovani, A.

PY - 2002/12

Y1 - 2002/12

N2 - Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p

AB - Previous findings demonstrated an altered pattern of amyloid precursor protein (APP) forms in platelets of Alzheimer disease (AD) patients, compared both with healthy control subjects or patients with non-Alzheimer-type dementia. The present study aims to evaluate whether platelet APP form ratio (APPr) is altered in patients with early stage AD. We selected 40 patients with early stage AD and 40 age-matched healthy controls. Compared with controls (mean±SD=0.91±0.3), mean APPr was decreased in AD (mean±SD=0.46±0.26, p

KW - Amyloid precursor protein

KW - Diagnosis

KW - Early stage Alzheimer disease

KW - Platelets

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Early stages of probable Alzheimer disease are associated with changes in platelet amyloid precursor protein forms

Abstract

Keywords

ASJC Scopus subject areas

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