Early treatment of acute graft-versus-host disease with high- or low- dose 6-methylprednisolone: A multicenter randomized trial from the Italian group for bone marrow transplantation

M. T. Van Lint, C. Uderzo, A. Locasciulli, I. Majolino, R. Scimé, F. Locatelli, G. Giorgiani, W. Arcese, A. P. Iori, M. Falda, F. Locatelli, A. Bosi, R. Miniero, P. Alessandrino, G. Dini, B. Rotoli, A. Bacigalupo

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Abstract

Ninety-five patients undergoing an allogeneic bone marrow transplant (BMT) and developing acute graft-versus-host disease (aGvHD) were randomized to receive low-dose intravenous 6-methylprednisolone (6MPred; 2 mg/kg/d; n = 47) or high-dose 6MPred (10 mg/kg/d; n = 48) for 5 days, with subsequent tapering doses. On day 5 patients not responding or progressing on low-dose 6MPred could be switched to high-dose 6MPred. All patients, aged 1 to 55 years, were recipients of unmanipulated BMT from HLA identical sibling donors. Patients were stratified at randomization for age (

Original languageEnglish
Pages (from-to)2288-2293
Number of pages6
JournalBlood
Volume92
Issue number7
Publication statusPublished - Oct 1 1998

ASJC Scopus subject areas

  • Hematology

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    Van Lint, M. T., Uderzo, C., Locasciulli, A., Majolino, I., Scimé, R., Locatelli, F., Giorgiani, G., Arcese, W., Iori, A. P., Falda, M., Locatelli, F., Bosi, A., Miniero, R., Alessandrino, P., Dini, G., Rotoli, B., & Bacigalupo, A. (1998). Early treatment of acute graft-versus-host disease with high- or low- dose 6-methylprednisolone: A multicenter randomized trial from the Italian group for bone marrow transplantation. Blood, 92(7), 2288-2293.