Early treatment with high-dose interferon beta-1a reverses cognitive and cortical plasticity deficits in multiple sclerosis

Francesco Mori, Hajime Kusayanagi, Fabio Buttari, Barbara Centini, Fabrizia Monteleone, Carolina Gabri Nicoletti, Giorgio Bernardi, Elisabetta Verdun Di Cantogno, Maria Grazia Marciani, Diego Centonze

Research output: Contribution to journalArticle

Abstract

Acute inflammation is associated with cognitive deficits and alterations of cortical plasticity in multiple sclerosis (MS). We tested whether early treatment with high-dose interferon (IFN) beta-1a, known to reduce inflammatory activity, improves cortical function and cognitive deficits in MS. Eighty treatment-naïve relapsing-remitting MS (RRMS) patients received IFN beta-1a (44 mcg) subcutaneously three times per week. Cognitive performance and cortical plasticity were measured through the paced auditory serial addition test (PASAT) and intermittent theta burst stimulation (iTBS) before and up to two years after IFN beta-1a initiation. Before treatment, patients with gadolinium-enhancing lesions (Gd+) on MRI performed worse on the PASAT, and showed lower iTBS-induced plasticity, compared with Gd- patients. Six months after treatment initiation both PASAT and iTBS-induced plasticity improved in Gd+ and remained stable in Gd- patients. These results suggest that cognitive and synaptic plasticity deficits may be rescued during high-dose IFN beta-1a treatment in newly-diagnosed RRMS patients with Gd+ lesions.

Original languageEnglish
Pages (from-to)163-168
Number of pages6
JournalFunctional Neurology
Volume27
Issue number3
Publication statusPublished - Jul 2012

Keywords

  • Cognition
  • Inflammation
  • PASAT
  • Synaptic plasticity
  • Theta burst stimulation
  • Transcranial magnetic stimulation

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

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  • Cite this

    Mori, F., Kusayanagi, H., Buttari, F., Centini, B., Monteleone, F., Nicoletti, C. G., Bernardi, G., Di Cantogno, E. V., Marciani, M. G., & Centonze, D. (2012). Early treatment with high-dose interferon beta-1a reverses cognitive and cortical plasticity deficits in multiple sclerosis. Functional Neurology, 27(3), 163-168.