Early twenty-four-hour blood pressure elevation in subjects with parental hypertension

Gianfranco Parati, Antonella Ravogli, Silvia Trazzi, Alessandra Villani, Emanuela Mutti, Antonella Groppelli, Giuseppe Mancia

Research output: Contribution to journalArticle

Abstract

We studied 15 normotensive offspring of hypertensive parents, comparing them with 15 normotensive controls matched for sex, body mass index and age. In the offspring, both parents were hypertensive, while in the controls, neither parent was hypertensive. Blood pressure was measured at rest, dur ing a variety of laborat ory stressors (mental arithmetic, mirror drawing test, hand grip and cold pressor test), and was also monitored for 24 h in ambulatory condi tions (Spacelabs 5300 M, Richmond, Washington, USA). Resting mean and diasto lic blood pressures were higher (P <0.05) in the subjects with parental hypertension than in those without. The mean blood pressure rise induced by the laboratory stressors was not significan tly greater at any time in the subjects with hypertensive parents compared with controls. Twenty-four-hour systolic and mean blood pressures, however, were sign ificantly higher (P <0.05) in the subjects with hypertensive parents than in the controls. Thus the higher office blood pressure shown in the prehypertensive stage by subjects with parenta l hypertension is not due to hypersensitivity to stress, but represents an early and permanent blood pressure elevation.

Original languageEnglish
Pages (from-to)S64-S65
JournalJournal of Hypertension, Supplement
Volume7
Publication statusPublished - 1989

Keywords

  • Ambulatory blood pressure monitoring
  • Essential hypertension
  • Genetic hypertension
  • Laboratory stressors

ASJC Scopus subject areas

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Internal Medicine
  • Endocrinology

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    Parati, G., Ravogli, A., Trazzi, S., Villani, A., Mutti, E., Groppelli, A., & Mancia, G. (1989). Early twenty-four-hour blood pressure elevation in subjects with parental hypertension. Journal of Hypertension, Supplement, 7, S64-S65.