Early visual assessment in preterm infants with and without brain lesions: Correlation with visual and neurodevelopmental outcome at 12 months

Daniela Ricci, Domenico M. Romeo, Francesca Gallini, Michela Groppo, Laura Cesarini, Silvia Pisoni, Francesca Serrao, Patrizia Papacci, Ilaria Contaldo, Francesca Perrino, Claudia Brogna, Flaviana Bianco, Giovanni Baranello, Annalisa Sacco, Michela Quintiliani, Alessandra Ometto, Salvatore Cilauro, Fabio Mosca, Costantino Romagnoli, Mario G. RomeoFrances Cowan, Giovanni Cioni, Luca Ramenghi, Eugenio Mercuri

Research output: Contribution to journalArticle

Abstract

Background: Several studies have reported the development of various aspects of visual function in infancy and early childhood in both preterm and term-born infants, but only a few studies have focused on the predictive power of neonatal visual findings in infants with brain lesions. Aims: To explore visual findings at term age, and at 3 and 12. months corrected age in preterm infants (gestational age <33. weeks) with and without brain lesions; to compare the assessment at term age and at 12. months; and to assess the relationship between visual findings and neurodevelopmental outcome at 12. months. Study design: Cranial ultrasound scans (US) were classified in normal, mild or major abnormalities. One-hundred and forty-five infants were assessed with age specific tests for visual function at term age, and at 3 and 12. months. Neurodevelopmental assessment (Griffiths' Scales) was performed at 12. months. Results: A good correlation was found between early and late visual assessment and neurodevelopment outcome. Of the 121 infants with normal neonatal visual assessment, 119 were also normal at 12. months and 116 had normal developmental quotient. Of the 24 infants with abnormal neonatal visual assessment, 12 were also abnormal at 12. months. All the false positives had normalised by 3. months. Of the 35 infants with major US abnormalities, 20 had normal and 15 abnormal scores on the neonatal assessment. At 1. year 17 had normal and 18 abnormal scores. Conclusion: A normal visual assessment at term age is a good predictor of normal visual and neurodevelopmental outcome at 12. months. An abnormal visual examination in the neonatal period was a less reliable prognostic indicator, infant should be reassessed at 3. months.

Original languageEnglish
Pages (from-to)177-182
Number of pages6
JournalEarly Human Development
Volume87
Issue number3
DOIs
Publication statusPublished - Mar 2011

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynaecology

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    Ricci, D., Romeo, D. M., Gallini, F., Groppo, M., Cesarini, L., Pisoni, S., Serrao, F., Papacci, P., Contaldo, I., Perrino, F., Brogna, C., Bianco, F., Baranello, G., Sacco, A., Quintiliani, M., Ometto, A., Cilauro, S., Mosca, F., Romagnoli, C., ... Mercuri, E. (2011). Early visual assessment in preterm infants with and without brain lesions: Correlation with visual and neurodevelopmental outcome at 12 months. Early Human Development, 87(3), 177-182. https://doi.org/10.1016/j.earlhumdev.2010.12.003