Early weaning is beneficial to prevent atopic dermatitis occurrence in young children

F. Turati, Paola Bertuccio, C. Galeone, C. Pelucchi, L. Naldi, Jean‐Frangois ‐F Bach, C. La Vecchia, L. Chatenoud, Fabio Agostinis, Stefania Carminati, Iria Neri, Annalisa Patrizi, Michela Starace, Samantha Berti, Maria Francesca Gola, Massimo Gola, Alberto Martelli, Daniela Origgi, Lorenza Serradori, Anna Graziella BurroniGiulia Ciccarese, Michela Brena, Cristiana Colonna, Carlo Gelmetti, Susanna Esposito, Valentina Montinaro, Maria Francesca Patria, Walter Peves Rios, Claudia Tagliabue, Elena Fontana, Anna Belloni Fortina, Camilla Peccianti, Michele Pellegrino, Emanuele Trovato, Anna Di Landro, Massimo Menchini, Vera Quadri, Oriana Testagrossa, Attilio Boner, Pasquale Comberiati, Diego Peroni, Carlo Gelmetti

Research output: Contribution to journalArticle

Abstract

Background Epidemiological data on infant feeding practices and allergic diseases are controversial. The purpose of this study was to explore the association of early weaning with the occurrence of atopic dermatitis (AD). Methods We conducted a matched case-control study on incident physician-diagnosed AD in early childhood including 451 cases and 451 controls. Data on several factors, including feeding practices, were collected through an interviewer-administered questionnaire. Odds ratios (OR) and the corresponding 95% confidence intervals (CIs) were estimated through logistic regression models, conditioned on study center, age, sex, and period of interview, and adjusted for potential confounders. Results Early weaning, defined as the introduction of solid foods at 4 or 5 months of age, was inversely related to the risk of AD, with children weaned at 4 months having lower AD risk (OR = 0.41, 95% CI, 0.20-0.87) compared to those exclusively breastfed. Similar results were observed for weaning started at 5 months of age (OR = 0.39, 95% CI, 0.18-0.83). This association persisted when children with and without family history of allergy were considered separately. Prolonged partial breastfeeding (breastmilk plus milk formulas) was not associated with AD. Consistently, the introduction of a high number of different solid foods reduced the risk of AD (P trend = 0.02 at 4 months of age and P trend = 0.04 at 5 months). Conclusion Our data provide evidence against the preventing role of prolonged exclusive (but not partial) breastfeeding in AD occurrence and confirm recent results indicating a beneficial role of early weaning in AD.

Original languageEnglish
Pages (from-to)878-888
Number of pages11
JournalAllergy: European Journal of Allergy and Clinical Immunology
Volume71
Issue number6
DOIs
Publication statusPublished - Jun 1 2016

Keywords

  • atopic dermatitis
  • breastfeeding
  • case-control study
  • children
  • eczema

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Turati, F., Bertuccio, P., Galeone, C., Pelucchi, C., Naldi, L., Bach, JF. F., La Vecchia, C., Chatenoud, L., Agostinis, F., Carminati, S., Neri, I., Patrizi, A., Starace, M., Berti, S., Gola, M. F., Gola, M., Martelli, A., Origgi, D., Serradori, L., ... Gelmetti, C. (2016). Early weaning is beneficial to prevent atopic dermatitis occurrence in young children. Allergy: European Journal of Allergy and Clinical Immunology, 71(6), 878-888. https://doi.org/10.1111/all.12864