Abstract
A simple derivatisation of commercially available poly(ethylene-glycols) of different molecular weight followed by the reaction with the selected fluorinated organic molecule, perfluoro-tertbutanol, allowed an easy synthesis of several novel polymers of different fluorine content. The properties of the new materials as MRI agents were preliminarily investigated. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; for a few fluorinated polymeric candidates a good solubility in water was observed and MR imaging of the fluorinated polymer successfully provided images. Most interesting results were obtained with the sample of 1436 MW (24% fluorine content) that not only gave a spectrum with a single resonance line, but, most importantly, was tolerated in low doses when in vivo experiments on animals (mice) were conducted.
| Original language | English |
|---|---|
| Pages (from-to) | 172-177 |
| Number of pages | 6 |
| Journal | Journal of Fluorine Chemistry |
| Volume | 153 |
| DOIs | |
| Publication status | Published - 2013 |
Fingerprint
Keywords
- F NMR
- Fluorinated polymer
- Magnetic resonance imaging
- Perfluoro compounds
- Poly(ethylene-glycol)
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
- Organic Chemistry
- Physical and Theoretical Chemistry
- Environmental Chemistry
Cite this
Easily available, low cost 19F MRI agents : Poly(ethylene-glycol)- functionalized fluorinated ethers. / Biaggi, Cinzia; Benaglia, Maurizio; Ortenzi, Marco; Micotti, Edoardo; Perego, Carlo; De Simoni, Maria Grazia.
In: Journal of Fluorine Chemistry, Vol. 153, 2013, p. 172-177.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Easily available, low cost 19F MRI agents
T2 - Poly(ethylene-glycol)- functionalized fluorinated ethers
AU - Biaggi, Cinzia
AU - Benaglia, Maurizio
AU - Ortenzi, Marco
AU - Micotti, Edoardo
AU - Perego, Carlo
AU - De Simoni, Maria Grazia
PY - 2013
Y1 - 2013
N2 - A simple derivatisation of commercially available poly(ethylene-glycols) of different molecular weight followed by the reaction with the selected fluorinated organic molecule, perfluoro-tertbutanol, allowed an easy synthesis of several novel polymers of different fluorine content. The properties of the new materials as MRI agents were preliminarily investigated. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; for a few fluorinated polymeric candidates a good solubility in water was observed and MR imaging of the fluorinated polymer successfully provided images. Most interesting results were obtained with the sample of 1436 MW (24% fluorine content) that not only gave a spectrum with a single resonance line, but, most importantly, was tolerated in low doses when in vivo experiments on animals (mice) were conducted.
AB - A simple derivatisation of commercially available poly(ethylene-glycols) of different molecular weight followed by the reaction with the selected fluorinated organic molecule, perfluoro-tertbutanol, allowed an easy synthesis of several novel polymers of different fluorine content. The properties of the new materials as MRI agents were preliminarily investigated. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; for a few fluorinated polymeric candidates a good solubility in water was observed and MR imaging of the fluorinated polymer successfully provided images. Most interesting results were obtained with the sample of 1436 MW (24% fluorine content) that not only gave a spectrum with a single resonance line, but, most importantly, was tolerated in low doses when in vivo experiments on animals (mice) were conducted.
KW - F NMR
KW - Fluorinated polymer
KW - Magnetic resonance imaging
KW - Perfluoro compounds
KW - Poly(ethylene-glycol)
UR - http://www.scopus.com/inward/record.url?scp=84885930722&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84885930722&partnerID=8YFLogxK
U2 - 10.1016/j.jfluchem.2013.04.010
DO - 10.1016/j.jfluchem.2013.04.010
M3 - Article
VL - 153
SP - 172
EP - 177
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
SN - 0022-1139
ER -