Easily available, low cost 19F MRI agents

Poly(ethylene-glycol)- functionalized fluorinated ethers

Cinzia Biaggi, Maurizio Benaglia, Marco Ortenzi, Edoardo Micotti, Carlo Perego, Maria Grazia De Simoni

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

A simple derivatisation of commercially available poly(ethylene-glycols) of different molecular weight followed by the reaction with the selected fluorinated organic molecule, perfluoro-tertbutanol, allowed an easy synthesis of several novel polymers of different fluorine content. The properties of the new materials as MRI agents were preliminarily investigated. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; for a few fluorinated polymeric candidates a good solubility in water was observed and MR imaging of the fluorinated polymer successfully provided images. Most interesting results were obtained with the sample of 1436 MW (24% fluorine content) that not only gave a spectrum with a single resonance line, but, most importantly, was tolerated in low doses when in vivo experiments on animals (mice) were conducted.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalJournal of Fluorine Chemistry
Volume153
DOIs
Publication statusPublished - 2013

Fingerprint

Ethers
Ethylene Glycol
Fluorine
fluorine
ether
Magnetic resonance imaging
ethylene
Polyethylene glycols
Fluorocarbon Polymers
Ethylene Glycols
glycols
ethers
polymer
Costs and Cost Analysis
polymers
Chloroform
chloroform
resonance lines
cost
Solubility

Keywords

  • F NMR
  • Fluorinated polymer
  • Magnetic resonance imaging
  • Perfluoro compounds
  • Poly(ethylene-glycol)

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Environmental Chemistry

Cite this

Easily available, low cost 19F MRI agents : Poly(ethylene-glycol)- functionalized fluorinated ethers. / Biaggi, Cinzia; Benaglia, Maurizio; Ortenzi, Marco; Micotti, Edoardo; Perego, Carlo; De Simoni, Maria Grazia.

In: Journal of Fluorine Chemistry, Vol. 153, 2013, p. 172-177.

Research output: Contribution to journalArticle

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