Abstract
A simple derivatisation of commercially available poly(ethylene-glycols) of different molecular weight followed by the reaction with the selected fluorinated organic molecule, perfluoro-tertbutanol, allowed an easy synthesis of several novel polymers of different fluorine content. The properties of the new materials as MRI agents were preliminarily investigated. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; for a few fluorinated polymeric candidates a good solubility in water was observed and MR imaging of the fluorinated polymer successfully provided images. Most interesting results were obtained with the sample of 1436 MW (24% fluorine content) that not only gave a spectrum with a single resonance line, but, most importantly, was tolerated in low doses when in vivo experiments on animals (mice) were conducted.
Original language | English |
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Pages (from-to) | 172-177 |
Number of pages | 6 |
Journal | Journal of Fluorine Chemistry |
Volume | 153 |
DOIs | |
Publication status | Published - 2013 |
Keywords
- F NMR
- Fluorinated polymer
- Magnetic resonance imaging
- Perfluoro compounds
- Poly(ethylene-glycol)
ASJC Scopus subject areas
- Biochemistry
- Inorganic Chemistry
- Organic Chemistry
- Physical and Theoretical Chemistry
- Environmental Chemistry