Easily available, low cost 19F MRI agents: Poly(ethylene-glycol)- functionalized fluorinated ethers

Cinzia Biaggi, Maurizio Benaglia, Marco Ortenzi, Edoardo Micotti, Carlo Perego, Maria Grazia De Simoni

Research output: Contribution to journalArticle

Abstract

A simple derivatisation of commercially available poly(ethylene-glycols) of different molecular weight followed by the reaction with the selected fluorinated organic molecule, perfluoro-tertbutanol, allowed an easy synthesis of several novel polymers of different fluorine content. The properties of the new materials as MRI agents were preliminarily investigated. In all cases a single 19F signal at NMR in deuterated chloroform and D2O was registered; for a few fluorinated polymeric candidates a good solubility in water was observed and MR imaging of the fluorinated polymer successfully provided images. Most interesting results were obtained with the sample of 1436 MW (24% fluorine content) that not only gave a spectrum with a single resonance line, but, most importantly, was tolerated in low doses when in vivo experiments on animals (mice) were conducted.

Original languageEnglish
Pages (from-to)172-177
Number of pages6
JournalJournal of Fluorine Chemistry
Volume153
DOIs
Publication statusPublished - 2013

    Fingerprint

Keywords

  • F NMR
  • Fluorinated polymer
  • Magnetic resonance imaging
  • Perfluoro compounds
  • Poly(ethylene-glycol)

ASJC Scopus subject areas

  • Biochemistry
  • Inorganic Chemistry
  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Environmental Chemistry

Cite this