Abstract
Nasal obstruction is a leading symptom in patients with allergic rhinitis and depends on inflammation characterized by Th2 polarization. Thus, IFN-γ is typically deficient in allergic patients. It has been previously reported that ebastine is able to reduce Th2-dependent cytokines. The aim of this study is to preliminarily evaluate IFN-γ production by peripheral blood mononuclear cells (PBMNC) and clinical changes after a treatment with lyophilized ebastine in patients with persistent allergic rhinitis (PER). Ten patients with PER were evaluated, 7 males and 3 females (mean age 32.4 ± 6.2 years), all of whom received lyophilized ebastine (20 mg/daily) for 3 weeks. Total nasal symptom score (TSS), subjective evaluation score by visual analogue scale (VAS), and rhinomanometry were evaluated in all subjects before and after treatment. IFN-γ production by peripheral blood mononuclear cells (PBMNC) was evaluated using different stimuli, in un-treated and ebastine-treated allergic patients by ELISPOT. Ebastine treatment induced significant increase of IFN-γ production stimulated by grasses (p
| Original language | English |
|---|---|
| Pages (from-to) | 31-36 |
| Number of pages | 6 |
| Journal | Journal of Biological Regulators and Homeostatic Agents |
| Volume | 23 |
| Issue number | 1 |
| Publication status | Published - Jan 2009 |
Keywords
- IFN-γ production
- Lyophilized ebastine
- Nasal airflow
- Persistent allergic rhinitis
ASJC Scopus subject areas
- Oncology
- Endocrinology, Diabetes and Metabolism
- Physiology (medical)
- Immunology and Allergy
- Immunology
- Endocrinology
- Physiology
- Cancer Research