Ebastine increases IFN-γ production in patients with persistent allergic rhinitis

Giorgio Ciprandi, I. Cirillo, A. Pistorio, M. Di Gioacchino, D. Fenoglio

Research output: Contribution to journalArticle

Abstract

Nasal obstruction is a leading symptom in patients with allergic rhinitis and depends on inflammation characterized by Th2 polarization. Thus, IFN-γ is typically deficient in allergic patients. It has been previously reported that ebastine is able to reduce Th2-dependent cytokines. The aim of this study is to preliminarily evaluate IFN-γ production by peripheral blood mononuclear cells (PBMNC) and clinical changes after a treatment with lyophilized ebastine in patients with persistent allergic rhinitis (PER). Ten patients with PER were evaluated, 7 males and 3 females (mean age 32.4 ± 6.2 years), all of whom received lyophilized ebastine (20 mg/daily) for 3 weeks. Total nasal symptom score (TSS), subjective evaluation score by visual analogue scale (VAS), and rhinomanometry were evaluated in all subjects before and after treatment. IFN-γ production by peripheral blood mononuclear cells (PBMNC) was evaluated using different stimuli, in un-treated and ebastine-treated allergic patients by ELISPOT. Ebastine treatment induced significant increase of IFN-γ production stimulated by grasses (p

Original languageEnglish
Pages (from-to)31-36
Number of pages6
JournalJournal of Biological Regulators and Homeostatic Agents
Volume23
Issue number1
Publication statusPublished - Jan 2009

Keywords

  • IFN-γ production
  • Lyophilized ebastine
  • Nasal airflow
  • Persistent allergic rhinitis

ASJC Scopus subject areas

  • Oncology
  • Endocrinology, Diabetes and Metabolism
  • Physiology (medical)
  • Immunology and Allergy
  • Immunology
  • Endocrinology
  • Physiology
  • Cancer Research

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