TY - JOUR
T1 - EBF2 regulates osteoblast-dependent differentiation of osteoclasts
AU - Kieslinger, Matthias
AU - Folberth, Stephanie
AU - Dobreva, Gergana
AU - Dorn, Tatjana
AU - Croci, Laura
AU - Erben, Reinhold
AU - Consalez, G. Giacomo
AU - Grosschedl, Rudolf
PY - 2005/12
Y1 - 2005/12
N2 - Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/ TCF:β-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.
AB - Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/ TCF:β-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.
UR - http://www.scopus.com/inward/record.url?scp=28444472781&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=28444472781&partnerID=8YFLogxK
U2 - 10.1016/j.devcel.2005.10.009
DO - 10.1016/j.devcel.2005.10.009
M3 - Article
C2 - 16326388
AN - SCOPUS:28444472781
VL - 9
SP - 757
EP - 767
JO - Developmental Cell
JF - Developmental Cell
SN - 1534-5807
IS - 6
ER -