EBF2 regulates osteoblast-dependent differentiation of osteoclasts

Matthias Kieslinger, Stephanie Folberth, Gergana Dobreva, Tatjana Dorn, Laura Croci, Reinhold Erben, G. Giacomo Consalez, Rudolf Grosschedl

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Abstract

Communication between bone-depositing osteoblasts and bone-resorbing osteoclasts is required for bone development and homeostasis. Here, we identify EBF2, a member of the early B cell factor (EBF) family of transcription factors that is expressed in osteoblast progenitors, as a regulator of osteoclast differentiation. We find that mice homozygous for a targeted inactivation of Ebf2 show reduced bone mass and an increase in the number of osteoclasts. These defects are accompanied by a marked downregulation of the osteoprotegerin (Opg) gene, encoding a RANK decoy receptor. EBF2 binds to sequences in the Opg promoter and transactivates the Opg promoter in synergy with the Wnt-responsive LEF1/ TCF:β-catenin pathway. Taken together, these data identify EBF2 as a regulator of RANK-RANKL signaling and osteoblast-dependent differentiation of osteoclasts.

Original languageEnglish
Pages (from-to)757-767
Number of pages11
JournalDevelopmental Cell
Volume9
Issue number6
DOIs
Publication statusPublished - Dec 2005

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ASJC Scopus subject areas

  • Developmental Biology

Cite this

Kieslinger, M., Folberth, S., Dobreva, G., Dorn, T., Croci, L., Erben, R., Consalez, G. G., & Grosschedl, R. (2005). EBF2 regulates osteoblast-dependent differentiation of osteoclasts. Developmental Cell, 9(6), 757-767. https://doi.org/10.1016/j.devcel.2005.10.009