EBUS-TBNA in mediastinal/hilar lymphadenopathies and/or masses: An Italian case series

Carlo Gurioli, Claudia Ravaglia, Micaela Romagnoli, Gianluca Casoni, Sara Tomassetti, Oriana Nanni, Venerino Poletti

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Introduction: Transbronchial needle aspiration (TBNA) is an established method to diagnose hilar/mediastinal lymphadenopathies and/or masses. Real-time endobronchial ultrasound (EBUS) is a method that involves TBNA, and has been shown to increase the diagnostic yield in this context. Objectives: A descriptive study has been conducted to test real-time EBUS in the diagnosis of hilar-mediastinal lymphadenopathies/masses with a shorter diameter less then 2.5cm or with a previous negative 'blind' TBNA. Methods: Consecutive patients referred for EBUS-TBNA of hilar/mediastinal lymph nodes were included in the study, when a node or mass was detected on a chest computed tomography scan. The primary end point was the number of successful biopsy specimens. Lymph node stations were classified according to the American Thoracic Society scheme. Results: Ninety-four patients (66 males, 28 females) of mean age 62years (range: 17-86) underwent EBUS-TBNA: EBUS-TBNA could be performed in all patients. The procedure was diagnostic in 80 patients (89.4%); positive samples were 73 (52 lung cancer, 18 sarcoidosis and 3 tuberculosis), negative samples were 17, inadequate specimens were obtained in four patients (4.25%) and surgically proven false negative results were found in six cases (6.38%). Biopsy specimens were taken from lymph nodes in region 2L (1 case), 2R (5 cases), 4R (20 cases), 4L (7 cases), 7 (47 cases), 10R (9 cases), 10L (2 cases), 11R (6 cases) and 11L (3 cases). Sensitivity was 92.4%, and specificity was 100%. No complications occurred. Conclusions: EBUS-TBNA is a safe and reliable method for sampling mediastinal lymph nodes.

Original languageEnglish
Pages (from-to)3-8
Number of pages6
JournalClinical Respiratory Journal
Volume6
Issue number1
DOIs
Publication statusPublished - Jan 2012

Fingerprint

Needles
Lymph Nodes
Biopsy
Sarcoidosis
Lymphadenopathy
Lung Neoplasms
Tuberculosis
Thorax
Tomography

Keywords

  • Endobronchial ultrasound
  • Mediastinal lymphadenopathies
  • ROSE
  • Transbronchial needle aspiration

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Immunology and Allergy
  • Genetics(clinical)

Cite this

EBUS-TBNA in mediastinal/hilar lymphadenopathies and/or masses : An Italian case series. / Gurioli, Carlo; Ravaglia, Claudia; Romagnoli, Micaela; Casoni, Gianluca; Tomassetti, Sara; Nanni, Oriana; Poletti, Venerino.

In: Clinical Respiratory Journal, Vol. 6, No. 1, 01.2012, p. 3-8.

Research output: Contribution to journalArticle

Gurioli, Carlo ; Ravaglia, Claudia ; Romagnoli, Micaela ; Casoni, Gianluca ; Tomassetti, Sara ; Nanni, Oriana ; Poletti, Venerino. / EBUS-TBNA in mediastinal/hilar lymphadenopathies and/or masses : An Italian case series. In: Clinical Respiratory Journal. 2012 ; Vol. 6, No. 1. pp. 3-8.
@article{ea8ab2526a5a45e59faf386ca2ab42e1,
title = "EBUS-TBNA in mediastinal/hilar lymphadenopathies and/or masses: An Italian case series",
abstract = "Introduction: Transbronchial needle aspiration (TBNA) is an established method to diagnose hilar/mediastinal lymphadenopathies and/or masses. Real-time endobronchial ultrasound (EBUS) is a method that involves TBNA, and has been shown to increase the diagnostic yield in this context. Objectives: A descriptive study has been conducted to test real-time EBUS in the diagnosis of hilar-mediastinal lymphadenopathies/masses with a shorter diameter less then 2.5cm or with a previous negative 'blind' TBNA. Methods: Consecutive patients referred for EBUS-TBNA of hilar/mediastinal lymph nodes were included in the study, when a node or mass was detected on a chest computed tomography scan. The primary end point was the number of successful biopsy specimens. Lymph node stations were classified according to the American Thoracic Society scheme. Results: Ninety-four patients (66 males, 28 females) of mean age 62years (range: 17-86) underwent EBUS-TBNA: EBUS-TBNA could be performed in all patients. The procedure was diagnostic in 80 patients (89.4{\%}); positive samples were 73 (52 lung cancer, 18 sarcoidosis and 3 tuberculosis), negative samples were 17, inadequate specimens were obtained in four patients (4.25{\%}) and surgically proven false negative results were found in six cases (6.38{\%}). Biopsy specimens were taken from lymph nodes in region 2L (1 case), 2R (5 cases), 4R (20 cases), 4L (7 cases), 7 (47 cases), 10R (9 cases), 10L (2 cases), 11R (6 cases) and 11L (3 cases). Sensitivity was 92.4{\%}, and specificity was 100{\%}. No complications occurred. Conclusions: EBUS-TBNA is a safe and reliable method for sampling mediastinal lymph nodes.",
keywords = "Endobronchial ultrasound, Mediastinal lymphadenopathies, ROSE, Transbronchial needle aspiration",
author = "Carlo Gurioli and Claudia Ravaglia and Micaela Romagnoli and Gianluca Casoni and Sara Tomassetti and Oriana Nanni and Venerino Poletti",
year = "2012",
month = "1",
doi = "10.1111/j.1752-699X.2010.00232.x",
language = "English",
volume = "6",
pages = "3--8",
journal = "Clinical Respiratory Journal",
issn = "1752-6981",
publisher = "Wiley-Blackwell",
number = "1",

}

TY - JOUR

T1 - EBUS-TBNA in mediastinal/hilar lymphadenopathies and/or masses

T2 - An Italian case series

AU - Gurioli, Carlo

AU - Ravaglia, Claudia

AU - Romagnoli, Micaela

AU - Casoni, Gianluca

AU - Tomassetti, Sara

AU - Nanni, Oriana

AU - Poletti, Venerino

PY - 2012/1

Y1 - 2012/1

N2 - Introduction: Transbronchial needle aspiration (TBNA) is an established method to diagnose hilar/mediastinal lymphadenopathies and/or masses. Real-time endobronchial ultrasound (EBUS) is a method that involves TBNA, and has been shown to increase the diagnostic yield in this context. Objectives: A descriptive study has been conducted to test real-time EBUS in the diagnosis of hilar-mediastinal lymphadenopathies/masses with a shorter diameter less then 2.5cm or with a previous negative 'blind' TBNA. Methods: Consecutive patients referred for EBUS-TBNA of hilar/mediastinal lymph nodes were included in the study, when a node or mass was detected on a chest computed tomography scan. The primary end point was the number of successful biopsy specimens. Lymph node stations were classified according to the American Thoracic Society scheme. Results: Ninety-four patients (66 males, 28 females) of mean age 62years (range: 17-86) underwent EBUS-TBNA: EBUS-TBNA could be performed in all patients. The procedure was diagnostic in 80 patients (89.4%); positive samples were 73 (52 lung cancer, 18 sarcoidosis and 3 tuberculosis), negative samples were 17, inadequate specimens were obtained in four patients (4.25%) and surgically proven false negative results were found in six cases (6.38%). Biopsy specimens were taken from lymph nodes in region 2L (1 case), 2R (5 cases), 4R (20 cases), 4L (7 cases), 7 (47 cases), 10R (9 cases), 10L (2 cases), 11R (6 cases) and 11L (3 cases). Sensitivity was 92.4%, and specificity was 100%. No complications occurred. Conclusions: EBUS-TBNA is a safe and reliable method for sampling mediastinal lymph nodes.

AB - Introduction: Transbronchial needle aspiration (TBNA) is an established method to diagnose hilar/mediastinal lymphadenopathies and/or masses. Real-time endobronchial ultrasound (EBUS) is a method that involves TBNA, and has been shown to increase the diagnostic yield in this context. Objectives: A descriptive study has been conducted to test real-time EBUS in the diagnosis of hilar-mediastinal lymphadenopathies/masses with a shorter diameter less then 2.5cm or with a previous negative 'blind' TBNA. Methods: Consecutive patients referred for EBUS-TBNA of hilar/mediastinal lymph nodes were included in the study, when a node or mass was detected on a chest computed tomography scan. The primary end point was the number of successful biopsy specimens. Lymph node stations were classified according to the American Thoracic Society scheme. Results: Ninety-four patients (66 males, 28 females) of mean age 62years (range: 17-86) underwent EBUS-TBNA: EBUS-TBNA could be performed in all patients. The procedure was diagnostic in 80 patients (89.4%); positive samples were 73 (52 lung cancer, 18 sarcoidosis and 3 tuberculosis), negative samples were 17, inadequate specimens were obtained in four patients (4.25%) and surgically proven false negative results were found in six cases (6.38%). Biopsy specimens were taken from lymph nodes in region 2L (1 case), 2R (5 cases), 4R (20 cases), 4L (7 cases), 7 (47 cases), 10R (9 cases), 10L (2 cases), 11R (6 cases) and 11L (3 cases). Sensitivity was 92.4%, and specificity was 100%. No complications occurred. Conclusions: EBUS-TBNA is a safe and reliable method for sampling mediastinal lymph nodes.

KW - Endobronchial ultrasound

KW - Mediastinal lymphadenopathies

KW - ROSE

KW - Transbronchial needle aspiration

UR - http://www.scopus.com/inward/record.url?scp=84155164446&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84155164446&partnerID=8YFLogxK

U2 - 10.1111/j.1752-699X.2010.00232.x

DO - 10.1111/j.1752-699X.2010.00232.x

M3 - Article

C2 - 21801328

AN - SCOPUS:84155164446

VL - 6

SP - 3

EP - 8

JO - Clinical Respiratory Journal

JF - Clinical Respiratory Journal

SN - 1752-6981

IS - 1

ER -