EBV-associated lymphoproliferative disorders: Classification and treatment

Antonino Carbone, Annunziata Gloghini, Giampietro Dotti

Research output: Contribution to journalArticlepeer-review

Abstract

Since its discovery as the first human tumor virus, Epstein-Barr virus (EBV) has been implicated in the development of a wide range of B-cell lymphoproliferative disorders, including Burkitt's lymphoma, classic Hodgkin's lymphoma, and lymphomas arising in immunocompromised individuals (post-transplant and HIV-associated lymphoproliferative disorders). T-cell lymphoproliferative disorders that have been reported to be EBV associated include a subset of peripheral T-cell lymphomas, angioimmunoblastic T-cell lymphoma, extranodal nasal type natural killer/ T-cell lymphoma, and other rare histotypes. EBV encodes a series of products interacting with or exhibiting homology to a wide variety of antiapoptotic molecules, cytokines, and signal transducers, hence promoting EBV infection, immortalization, and transformation. However, the exact mechanism by which EBV promotes oncogenesis is an area of active debate. The focus of this review is on the pathology, diagnosis, classification, and pathogenesis of EBV-associated lymphomas. Recent advances in EBV cell-based immunotherapy, which is beginning to show promise in the treatment of EBV-related disorders, are discussed.

Original languageEnglish
Pages (from-to)577-585
Number of pages9
JournalThe oncologist
Volume13
Issue number5
DOIs
Publication statusPublished - May 2008

Keywords

  • EBV
  • EBV cell-based immunotherapy
  • EBV-associated lymphomas
  • HIV-associated lymphoproliferative disorders
  • Post-transplant-associated lymphoproliferative disorders

ASJC Scopus subject areas

  • Cancer Research
  • Hematology

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