EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15

Julien Giron-Michel, Fanny Menard, Simone Negrini, Aurore Devocelle, Bruno Azzarone, Caroline Besson

Research output: Contribution to journalArticlepeer-review

Abstract

It has been reported that infectious mononucleosis (IM)-symptomatic primary Epstein-Barr virus infection produces a global down-regulation of interleukin-15 receptor-α (IL-15Rα) on T cells and natural killer cells associated with a defective IL-15 responsiveness that lasts for many years after the disease episode. In contrast with these results, our data indicate that, in the T-cell compartment derived from remote IM subjects, there is no quantitative or qualitative defect in the expression of the IL-15Rα chain and no deficit in T-cell responsiveness to IL-15. We observed efficient signal transduction, survival, and proliferation even in response to low IL-15 concentrations. These data are relevant and shed new light on the immune long-term response in IM subjects because they contradict the hypothesis that defects in Epstein-Barr virus-host immune balance may be correlated with a long-lasting global deficit in T-cell responsiveness to IL-15.

Original languageEnglish
Pages (from-to)4541-4547
Number of pages7
JournalBlood
Volume113
Issue number19
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Immunology
  • Hematology

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