EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15

Julien Giron-Michel, Fanny Menard, Simone Negrini, Aurore Devocelle, Bruno Azzarone, Caroline Besson

Research output: Contribution to journalArticle

Abstract

It has been reported that infectious mononucleosis (IM)-symptomatic primary Epstein-Barr virus infection produces a global down-regulation of interleukin-15 receptor-α (IL-15Rα) on T cells and natural killer cells associated with a defective IL-15 responsiveness that lasts for many years after the disease episode. In contrast with these results, our data indicate that, in the T-cell compartment derived from remote IM subjects, there is no quantitative or qualitative defect in the expression of the IL-15Rα chain and no deficit in T-cell responsiveness to IL-15. We observed efficient signal transduction, survival, and proliferation even in response to low IL-15 concentrations. These data are relevant and shed new light on the immune long-term response in IM subjects because they contradict the hypothesis that defects in Epstein-Barr virus-host immune balance may be correlated with a long-lasting global deficit in T-cell responsiveness to IL-15.

Original languageEnglish
Pages (from-to)4541-4547
Number of pages7
JournalBlood
Volume113
Issue number19
DOIs
Publication statusPublished - 2009

Fingerprint

Interleukin-15
T-cells
Human Herpesvirus 4
Infectious Mononucleosis
Interleukin-15 Receptors
T-Lymphocytes
Viruses
Signal transduction
Defects
Epstein-Barr Virus Infections
Natural Killer Cells
Signal Transduction
Down-Regulation

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Immunology
  • Hematology

Cite this

Giron-Michel, J., Menard, F., Negrini, S., Devocelle, A., Azzarone, B., & Besson, C. (2009). EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15. Blood, 113(19), 4541-4547. https://doi.org/10.1182/blood-2008-12-195289

EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15. / Giron-Michel, Julien; Menard, Fanny; Negrini, Simone; Devocelle, Aurore; Azzarone, Bruno; Besson, Caroline.

In: Blood, Vol. 113, No. 19, 2009, p. 4541-4547.

Research output: Contribution to journalArticle

Giron-Michel, J, Menard, F, Negrini, S, Devocelle, A, Azzarone, B & Besson, C 2009, 'EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15', Blood, vol. 113, no. 19, pp. 4541-4547. https://doi.org/10.1182/blood-2008-12-195289
Giron-Michel, Julien ; Menard, Fanny ; Negrini, Simone ; Devocelle, Aurore ; Azzarone, Bruno ; Besson, Caroline. / EBV-associated mononucleosis does not induce long-term global deficit in T-cell responsiveness to IL-15. In: Blood. 2009 ; Vol. 113, No. 19. pp. 4541-4547.
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