Ebv-driven lymphoproliferative disorders and lymphomas of the gastrointestinal tract: A spectrum of entities with a common denominator (part 2)

Magda Zanelli, Francesca Sanguedolce, Andrea Palicelli, Maurizio Zizzo, Giovanni Martino, Cecilia Caprera, Valentina Fragliasso, Alessandra Soriano, Luca Valle, Stefano Ricci, Fabrizio Gozzi, Luca Cimino, Alberto Cavazza, Francesco Merli, Stefano A. Pileri, Stefano Ascani

Research output: Contribution to journalReview articlepeer-review

Abstract

Epstein–Barr virus (EBV) is a common pathogen infecting people primarily early in life. The virus has the ability to persist throughout a person’s life, usually in B lymphocytes. Conditions of immunodeficiency as well as the introduction of immunosuppressive therapies and the advent of transplant technologies has brought immunodeficiency-associated lymphoproliferative disorders into view, which are often driven by EBV. The group of EBV-associated lymphoproliferative disorders includes different entities, with distinct biological features, ranging from indolent disor-ders, which may even spontaneously regress, to aggressive lymphomas requiring prompt and ade-quate treatment. These disorders are often diagnostically challenging due to their overlapping mor-phology and immunophenotype. Both nodal and extra-nodal sites, including the gastrointestinal tract, may be involved. This review, divided in three parts, summarizes the clinical, pathological, molecular features and treatment strategies of EBV-related lymphoproliferative disorders occurring in the gastrointestinal tract and critically analyzes the major issues in the differential diagnosis. In this part of the review, we discuss plasmablastic lymphoma, extra-cavitary primary effusion lymphoma and Burkitt lymphoma.

Original languageEnglish
Article number4527
JournalCancers
Volume13
Issue number18
DOIs
Publication statusPublished - Sep 2021

Keywords

  • Burkitt lymphoma
  • Epstein–Barr virus
  • Plasmablastic lymphoma
  • Primary effusion lymphoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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