Based on current knowledge, it is evident that EBV may actively shape lymphoma microenvironment, which is emerging as an essential component of the tumor. The virus orchestrates a variety of complex mechanisms favoring the escape of lymphoma cells from antitumor immune responses while promoting the creation of niches in which tumor cells may find support for their growth and survival. EBV is also able to promote neo-angiogenesis and evidence mainly obtained in epithelial cells indicates that the virus may also promote tumor cell invasion and dissemination. Elucidation of the role of tumor microenvironment in the pathogenesis of lymphoid malignancies is providing the framework for identifying and validating novel therapies that target both lymphoma cells and critical microenvironmental factors. EBVdriven lymphoid malignancies, however, offer additional targets of therapy provided by EBV-induced pathways shaping tumor microenvironment, which can be exploited to further improve current therapeutic strategies.
|Title of host publication||Hodgkin and Non-Hodgkin Lymphomas Seen through Their Microenvironment: Impact on Diagnosis, Prognosis and Innovative Therapy|
|Publisher||Future Medicine Ltd.|
|Number of pages||13|
|ISBN (Print)||9781780845791, 9781780845814|
|Publication status||Published - May 1 2015|
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