Eccrine syringofibroadenoma and clear cell acanthoma: An association by chance?

Carlo Cota, Gerardo Ferrara, Ada Amantea, Pietro Donati

Research output: Contribution to journalArticlepeer-review

Abstract

A 58-year-old white woman with stasis dermatitis developed a solitary, slowly growing keratotic nodule of the dorsum of the foot. The excision biopsy specimen of this lesion showed a biphasic pattern of eccrine syringofibroadenoma and clear cell acanthoma. Such a previously unreported association is neither necessarily by chance nor necessarily a collision. Because a reactive histogenesis has been postulated for both eccrine syringofibroadenoma and clear cell acanthoma, this case could represent a morphologically biphasic pattern of epidermal and ductal hyperplasia as a consequence of the stasis-induced chronic inflammation coupled with the footwear-induced chronic trauma.

Original languageEnglish
Pages (from-to)195-198
Number of pages4
JournalAmerican Journal of Dermatopathology
Volume33
Issue number2
DOIs
Publication statusPublished - Apr 2011

Keywords

  • clear cell acanthoma
  • Eccrine syringofibroadenoma
  • immunohistochemistry
  • reactive eccrine syringofibroadenomatous hyperplasia
  • stasis dermatitis

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology

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