Echo-Doppler evaluation of acute flow changes in portal hypertensive patients: flow velocity as a reliable parameter

Carlo Sabbà, Giovanna Ferraioli, Paolo Buonamico, Elsa Berardi, Gianfranco Antonica, Kenneth J W Taylor, Ottavio Albano

Research output: Contribution to journalArticle

Abstract

In order to evaluate the behavior of the portal vein cross-sectional area during changes in portal flow, two groups of subjects were analyzed in two blinded cross- over studies using echo-Doppler flowmetry. The first group (I) consisted of 21 patients with cirrhosis and 16 controls. They received a standardized meal which is known to increase portal flow. The second group (II) consisted of 31 patients with cirrhosis who received a dose of propranolol which is known to decrease portal flow. In Group I, 30 min after the meal, the portal vein blood velocity increased by 35 ± 6% (p <0.01) in cirrhotic patients and by 55 ± 5% (p <0.01), in normal subjects. The portal vein cross-sectional area increased significantly in normal subjects (22 ± 2%, p <0.01) but not in cirrhotic patients (4 ± 2%, n.s.). In Group II, 2 h after propranolol, there was a significant decrease in portal blood velocity (- 14 ± 2%), whereas the portal vein cross-sectional area did not show any significant changes. These data demonstrate that, in portal hypersensitive patients, the portal area measured by echo-Doppler flowmetry can be assumed to be constant and hence its calculation to estimate changes in portal blood flow can be omitted. Therefore, the use of blood velocity alone is suggested to monitor acute changes in flow in portal hypertension using Doppler flowmetry. The elimination of the portal vein cross-sectional area measurement simplifies the quantitative calculation of portal hemodynamics and increases the reliability of the technique by avoiding a source of error.

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalJournal of Hepatology
Volume15
Issue number3
DOIs
Publication statusPublished - 1992

Keywords

  • Blood flow measurements
  • Cirrhosis
  • Doppler studies
  • Splanchnic vessels
  • Ultrasound

ASJC Scopus subject areas

  • Gastroenterology

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