Echocardiographic abnormalities in normotensive obese patients: Relationship with visceral fat

Lelio Morricone, Alexis Elias Malavazos, Calin Coman, Cristina Donati, Tamin Hassan, Francesco Caviezel

Research output: Contribution to journalArticle

Abstract

Objective: To evaluate the relationship of echocardiographic characteristics and visceral adipose tissue (VAT) distribution in normotensive obese patients. Research Methods and Procedures: Echocardiographic parameters were assessed in 28 normotensive obese patients [7 men, 21 women, mean age, 43.2 years; mean body mass index (BMI), 37.2 kg/m2; 10 with impaired glucose tolerance (IGT); 6 with type 2 diabetes] and 18 sex-and age-matched healthy, normal-weight controls (4 men, 14 women; mean age, 45.8 years; mean BMI, 22.4 kg/m2) by an M-mode, color-doppler videofluoroscope. VAT in the obese patients was assessed by computed tomography (at L4 level). Results: The obese patients had a significantly larger internal diastolic left ventricular (LV) diameter (p <0.05), a thicker end-diastolic septum (p <0.001) and posterior wall (p <0.001), a greater indexed (g/m2.7) LV mass (p <0.001), a higher atrial diastolic filling wave velocity (p <0.001), a lower ratio between early and atrial diastolic filling wave velocities (p <0.01), and a prolonged isovolumic relaxation time (p <0.05). End-diastolic septum and posterior wall thickness and the LV mass were significantly greater in patients with a VAT area > 130 cm2 than with 2. In the multivariate regression analysis, only VAT (p <0.0001), waist-to-hip ratio (p <0.001), and sex (p <0.001) were associated with the most important echocardiographic alterations. Discussion: The morphological and functional echocardiographic alterations usually found in normotensive obese patients closely correlate with the amount of intra-abdominal fat deposition, even in the presence of diabetes or IGT.

Original languageEnglish
Pages (from-to)489-498
Number of pages10
JournalObesity Research
Volume10
Issue number6
Publication statusPublished - Jun 2002

Keywords

  • Computed tomography
  • Diabetes
  • Echocardiographic abnormalities
  • Visceral adipose tissue

ASJC Scopus subject areas

  • Food Science
  • Endocrinology
  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Public Health, Environmental and Occupational Health

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    Morricone, L., Malavazos, A. E., Coman, C., Donati, C., Hassan, T., & Caviezel, F. (2002). Echocardiographic abnormalities in normotensive obese patients: Relationship with visceral fat. Obesity Research, 10(6), 489-498.