Echocardiographic aortic root dilatation in hypertensive patients: A systematic reviewand meta-analysis

Michele Covella, Alberto Milan, Silvia Totaro, Cesare Cuspidi, Annalisa Re, Franco Rabbia, Franco Veglio

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: The risk of thoracic aortic dissection is strictly related to the diameter of the ascending aorta. Arterial hypertension represents a major risk factor for the development of aortic dissection and is thought to be directly involved in the pathogenesis of aortic aneurysms. Recent studies have suggested a high prevalence of aortic root enlargement in the hypertensive population, but evidence of a direct link between blood pressure values and size of the aortic root has been inconclusive so far. The aim of the current study was to evaluate prevalence of aortic root dilatation (ARD) in the hypertensive population and to assess the correlates of this condition. Methods: Medical literature was reviewed to identify articles assessing prevalence of echocardiographic ARD in hypertensive patients. Results: A total of eight studies including 10 791 hypertensive patients were considered. Prevalence of ARD in the pooled population was 9.1% with a marked difference between men and women (12.7 vs. 4.5%; odds ratio 3.15; 95% confidence interval 2.68-3.71). Hypertensive patients with ARD and those with normal aortic root size had similar office blood pressure values, but the former were older and had a significantly higher left-ventricular mass (0.52 SDs, 95% confidence interval 0.41-0.63). Conclusion: ARD is a common phenotype in hypertensive patients, with men showing a markedly higher susceptibility, but office blood pressure values do not appear to be directly associated with aortic root diameter.

Original languageEnglish
Pages (from-to)1928-1935
Number of pages8
JournalJournal of Hypertension
Volume32
Issue number10
DOIs
Publication statusPublished - Oct 1 2014

Fingerprint

Meta-Analysis
Dilatation
Blood Pressure
Dissection
Confidence Intervals
Population
Aortic Aneurysm
Aorta
Thorax
Odds Ratio
Hypertension
Phenotype

Keywords

  • Aortic root dilatation
  • Aortic root enlargement
  • Hypertensive target organ damage
  • Sinuses of Valsalva
  • Thoracic aorta aneurysm
  • Transthoracic echocardiography

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

Cite this

Echocardiographic aortic root dilatation in hypertensive patients : A systematic reviewand meta-analysis. / Covella, Michele; Milan, Alberto; Totaro, Silvia; Cuspidi, Cesare; Re, Annalisa; Rabbia, Franco; Veglio, Franco.

In: Journal of Hypertension, Vol. 32, No. 10, 01.10.2014, p. 1928-1935.

Research output: Contribution to journalArticle

Covella, Michele ; Milan, Alberto ; Totaro, Silvia ; Cuspidi, Cesare ; Re, Annalisa ; Rabbia, Franco ; Veglio, Franco. / Echocardiographic aortic root dilatation in hypertensive patients : A systematic reviewand meta-analysis. In: Journal of Hypertension. 2014 ; Vol. 32, No. 10. pp. 1928-1935.
@article{94961fccb0734844ad69544f3deee116,
title = "Echocardiographic aortic root dilatation in hypertensive patients: A systematic reviewand meta-analysis",
abstract = "Objective: The risk of thoracic aortic dissection is strictly related to the diameter of the ascending aorta. Arterial hypertension represents a major risk factor for the development of aortic dissection and is thought to be directly involved in the pathogenesis of aortic aneurysms. Recent studies have suggested a high prevalence of aortic root enlargement in the hypertensive population, but evidence of a direct link between blood pressure values and size of the aortic root has been inconclusive so far. The aim of the current study was to evaluate prevalence of aortic root dilatation (ARD) in the hypertensive population and to assess the correlates of this condition. Methods: Medical literature was reviewed to identify articles assessing prevalence of echocardiographic ARD in hypertensive patients. Results: A total of eight studies including 10 791 hypertensive patients were considered. Prevalence of ARD in the pooled population was 9.1{\%} with a marked difference between men and women (12.7 vs. 4.5{\%}; odds ratio 3.15; 95{\%} confidence interval 2.68-3.71). Hypertensive patients with ARD and those with normal aortic root size had similar office blood pressure values, but the former were older and had a significantly higher left-ventricular mass (0.52 SDs, 95{\%} confidence interval 0.41-0.63). Conclusion: ARD is a common phenotype in hypertensive patients, with men showing a markedly higher susceptibility, but office blood pressure values do not appear to be directly associated with aortic root diameter.",
keywords = "Aortic root dilatation, Aortic root enlargement, Hypertensive target organ damage, Sinuses of Valsalva, Thoracic aorta aneurysm, Transthoracic echocardiography",
author = "Michele Covella and Alberto Milan and Silvia Totaro and Cesare Cuspidi and Annalisa Re and Franco Rabbia and Franco Veglio",
year = "2014",
month = "10",
day = "1",
doi = "10.1097/HJH.0000000000000286",
language = "English",
volume = "32",
pages = "1928--1935",
journal = "Journal of Hypertension",
issn = "0263-6352",
publisher = "Lippincott Williams and Wilkins",
number = "10",

}

TY - JOUR

T1 - Echocardiographic aortic root dilatation in hypertensive patients

T2 - A systematic reviewand meta-analysis

AU - Covella, Michele

AU - Milan, Alberto

AU - Totaro, Silvia

AU - Cuspidi, Cesare

AU - Re, Annalisa

AU - Rabbia, Franco

AU - Veglio, Franco

PY - 2014/10/1

Y1 - 2014/10/1

N2 - Objective: The risk of thoracic aortic dissection is strictly related to the diameter of the ascending aorta. Arterial hypertension represents a major risk factor for the development of aortic dissection and is thought to be directly involved in the pathogenesis of aortic aneurysms. Recent studies have suggested a high prevalence of aortic root enlargement in the hypertensive population, but evidence of a direct link between blood pressure values and size of the aortic root has been inconclusive so far. The aim of the current study was to evaluate prevalence of aortic root dilatation (ARD) in the hypertensive population and to assess the correlates of this condition. Methods: Medical literature was reviewed to identify articles assessing prevalence of echocardiographic ARD in hypertensive patients. Results: A total of eight studies including 10 791 hypertensive patients were considered. Prevalence of ARD in the pooled population was 9.1% with a marked difference between men and women (12.7 vs. 4.5%; odds ratio 3.15; 95% confidence interval 2.68-3.71). Hypertensive patients with ARD and those with normal aortic root size had similar office blood pressure values, but the former were older and had a significantly higher left-ventricular mass (0.52 SDs, 95% confidence interval 0.41-0.63). Conclusion: ARD is a common phenotype in hypertensive patients, with men showing a markedly higher susceptibility, but office blood pressure values do not appear to be directly associated with aortic root diameter.

AB - Objective: The risk of thoracic aortic dissection is strictly related to the diameter of the ascending aorta. Arterial hypertension represents a major risk factor for the development of aortic dissection and is thought to be directly involved in the pathogenesis of aortic aneurysms. Recent studies have suggested a high prevalence of aortic root enlargement in the hypertensive population, but evidence of a direct link between blood pressure values and size of the aortic root has been inconclusive so far. The aim of the current study was to evaluate prevalence of aortic root dilatation (ARD) in the hypertensive population and to assess the correlates of this condition. Methods: Medical literature was reviewed to identify articles assessing prevalence of echocardiographic ARD in hypertensive patients. Results: A total of eight studies including 10 791 hypertensive patients were considered. Prevalence of ARD in the pooled population was 9.1% with a marked difference between men and women (12.7 vs. 4.5%; odds ratio 3.15; 95% confidence interval 2.68-3.71). Hypertensive patients with ARD and those with normal aortic root size had similar office blood pressure values, but the former were older and had a significantly higher left-ventricular mass (0.52 SDs, 95% confidence interval 0.41-0.63). Conclusion: ARD is a common phenotype in hypertensive patients, with men showing a markedly higher susceptibility, but office blood pressure values do not appear to be directly associated with aortic root diameter.

KW - Aortic root dilatation

KW - Aortic root enlargement

KW - Hypertensive target organ damage

KW - Sinuses of Valsalva

KW - Thoracic aorta aneurysm

KW - Transthoracic echocardiography

UR - http://www.scopus.com/inward/record.url?scp=84925718751&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84925718751&partnerID=8YFLogxK

U2 - 10.1097/HJH.0000000000000286

DO - 10.1097/HJH.0000000000000286

M3 - Article

C2 - 24979304

AN - SCOPUS:84925718751

VL - 32

SP - 1928

EP - 1935

JO - Journal of Hypertension

JF - Journal of Hypertension

SN - 0263-6352

IS - 10

ER -