To assess the morphologic and functional cardiac effects of long-term antihypertensive treatment with metroprolol, thirty established hypertensives with a satisfactory control of blood pressure with metoprolol alone (200 mg/daily) (n=13) or combined with chlorthalidone (100-400 mg/weekly) (n=17) were studied. An echocardiographic evaluation was performed before, after 6 months and after 1 year of stable antihypertensive regimen. After 6 months, the morphologic and functional echocardiographic indices remained unchanged. On the contrary, after 12 months there was a reduction of left ventricle end-diastolic and end-systolic diameters and an increase in left ventricular ejection fraction. Furthermore, the intercept of the multiple regression of circumferential fiber shortening velocity versus heart rate and systolic blood pressure, used as a more reliable index of left ventricular performance, remained unchanged during treatment. Our results confirm that cardiac hypertrophy is an adaptive response of the myocardium to chronically increased work loads, and suggest that metroprolol may be safely employed in hypertensives in view of its irrelevant negative cardiac inotropic effects.
|Number of pages||11|
|Journal||Current Therapeutic Research|
|Issue number||6 II|
|Publication status||Published - 1980|
ASJC Scopus subject areas